Metabolite biomarker case study
Anti-L-kynurenine antibody for IHC and ELISA detection
Essential amino acid L-Tryptophan is converted to L-Kynurenine either through indoleamine-2,3-dioxygenase 1/2 (IDO1/2) or tryptophan-2,3-oxygenase (TDO2) enzymes. Abnormal tryptophan metabolism along the kynurenine pathway has been shown to promote tumor immune espace as well as neurodegenerative disorders and infectious diseases.
Direct detection of L-Kynurenine is therefore critical to stratify patients harboring exaggerated tryptophan catabolism and to assess the efficacy of drug candidates targeting IDO1, IDO2 and/or TDO2.