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Kynurenine/Kynurenic Acid/Quinolinic Acid ELISA pack (3-KYNs ELISA pack)
Ref: ISE-220102RKynurenine pathwayTryptophan metabolismResearch ELISA kits (RUO)ELISA
+Kynurenine/Kynurenic Acid/Quinolinic Acid ELISA pack (3-KYNs ELISA pack)
DatasheetMSDS KynurenineProtocol KynurenineMSDS Kynurenic AcidProtocol Kynurenic AcidMSDS Quinolinic AcidProtocol Quinolinic Acid
The Kynurenine/Kynurenic Acid/Quinolinic acid ELISA pack enables quantitative measurements of tryptophan catabolism along the kynurenine pathway in large numbers of samples. Intended for research use only, the three kits included in the pack are ready to use. Highly sensitive, with a minimum sample volume of 25-50µL, they enable pre-clinical and clinical sample testings.
| Sample type | Plasma, Serum |
| Kit capacity | 3 x 96 tests |
| Sensitivity | LoD KYN: 47.5ng/ml LoD KYNA: 0.53ng/ml LoD QA: 6ng/ml |
| Range | KYN: 100 – 10000ng/ml KYNA: 1.40 – 74ng/ml |
| Reactivity | Reacts with all species |
| References | Individual kits cited in over 40 papers |
Product overview
| Product name | Kynurenine/Kynurenic Acid/Quinolinic Acid ELISA pack |
| Description | Three enzyme immunoassays (ELISA) allowing the quantitative determination of L-Kynurenine, Kynurenic acid and Quinolinic acid in serum samples. For research use only |
| Labels | RUO |
| Format | 3 x 96-well plate |
| Samples | Serum |
| Minimum sample volume | 20-50µL |
| Reactivity | Reacts with all species |
| Standard range | KYN: 100 – 10000ng/ml KYNA: 1.40 – 74ng/mlQA: 200 – 2000µg/ml |
| Sensitivity | LoD KYN: 47.5ng/ml LoD QA: 6ng/ml |
| Specificity | No significant cross-reactivity was observed analogs for each kit. See product pages for L-Kynurenine ELISA, Kynurenic acid ELISA and Quinolinic acid ELISA |
| Storage | Store at 2-8°C for to 6 months |
| Datasheets | Instructions for use – KYN kit, Instructions for use – KYNA kit, Instructions for use – QA kit |
| Sample collection & storage | Serum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands. Store samples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months) |
| Sample preparation | KYN: Sample acylation (90 min) KYNA: Sample derivatization (90 min) |
| ELISA | Antisera overnight incubation, revelation and read steps (1h) |
| Detailed protocol | Instructions for use – KYN kit, Instructions for use – KYNA kit, Instructions for use – QA kit |
Product citation
- Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress
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Authors : Letenneur et al., Nutrients
2023-10 - Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study
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Authors : Onning et al., Nutrients
2023-08 - Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
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Authors : Dongen et al., bioRxiv
2023-07 - Advances in kynurenine analysis
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Authors : Mrstna et al., Clinica Chimica Acta
2023-07 - Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions
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Authors : Cremone et al., Biomedicines
2023-04 - Priming Mesenchymal Stem/Stromal Cells with a Combination of a Low Dose of IFN- and Bor_tezomib Results in Potent Suppression of Pathogenic Th17 Immunity Through the IDO1-AHR Axis
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Authors : Park et al., Stem Cells
2022-10 - IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma
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Authors : Struckmeier et al., Journal of Cancer Reasearch & Clinical Oncology
2022-08 - Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
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Authors : Sugisawa et al., Cell reports
2022-03 - Alzheimer’s-like signaling in brains of COVID-19 patients
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Authors : Reiken et al., Alzheimer's & Dementia
2022-02 - Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo
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Authors : Siska et al., eBioMedicine
2021-12 - Cancer-associated fibroblasts educate normal fibroblaststo facilitate cancer cell spreading and T-cell suppression
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Authors : Itoh et al., Molecular Oncology
2021-11 - Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma
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Authors : Pospíšková et al., Pteridines
2021-11 - Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway
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Authors : Kim et al., Oncoimmunology
2021-11 - Apathy is not associated with a panel of biomarkers in older adults with HIV disease
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Authors : Wood et al., Journal of psychosomatic research
2021-11 - Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives
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Authors : Sadok et al., Sensors
2021-10 - Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial
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Authors : Chaiyasut et al, Foods
2021-07 - STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer
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Authors : Lee et al., Journal of Immunotherapy of Cancer
2021-06 - Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways
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Authors : MacDowell et al., Frontiers in Pharmacology
2021-05 - Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza
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Authors : Jung Cho et al., European Respiratory Journal
2021-05 - IDO1-mediated Trp-kynurenine-AhR signal activation induces stemness and tumor dormancy in oral squamous cell carcinomas
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Authors : Anzai et al., Oral Science International
2021-04 - Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
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Authors : Bekki et al., PloS one
2020-10 - Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans
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Authors : Baumgartner et al., Journal of internal medicine
2020-08 - Effect of repetitive transcranial magnetic stimulation on the kynurenine pathway in stroke patients
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Authors : Masachika et al., Clinical neuroscience
2020-06 - Evaluating the potential role of tryptophan in calf milk replacers to facilitate weaning
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Authors : Yeste et al., Journal of Dairy Science
2020-05 - IDO Targeting in Sarcoma: Biological and Clinical Implications
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Authors : Nafia et al., Frontiers in immunology
2020-03 - Selective Killing of Activated T Cells by 5- Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
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Authors : Darvekar et al., Cancers
2020-02 - A highly efficient modality to block the degradation of tryptophan for cancer immunotherapy: locked nucleic acid-modified antisense oligonucleotides to inhibit human indoleamine 2,3-dioxygenase 1/tryptophan 2,3-dioxygenase expression
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Authors : Klar et al., Cancer Immunol Immunother
2020-01 - Physical exercise prevents mice from L-Kynurenine-induced depression-like behavior
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Authors : Su et al., Asian Journal of Psychatry
2019-12 - Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8 + T-Cell-Dependent Tumor Activity
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Authors : Watanabe et al., Clinical Cancer Research
2019-11 - Lactobacillus maintains healthy gut mucosa by producing L-Ornithine
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Authors : Qi et al., Communications Biology
2019-05 - Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway
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Authors : Allison et al., American Journal of Psycology
2019-01 - Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice
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Authors : Walker et al., Molecular Psychiatry
2018-07 - Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats
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Authors : Martin-Hernandez et al., Molecular Neurobiology
2018-05 - Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas: A Phase 2 Clinical Trial
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Authors : Toulmonde et al., JAMA oncology
2018-01 - Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections
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Authors : Ziklo et al., Frontiers in cellular and infection microbiology
2018-01 - In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis
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Authors : Gautam et al., Proceedings of the National Academy of Sciences of the USA
2018-01 - The peroxyl radical-induced oxidation of Escherichia coli FtsZ and its single tryptophan mutant (Y222W) modifies specific side-chains, generates protein cross-links and affects biological function
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Authors : Escobar-Alvarez et al., Free radical biology & medicine
2017-07 - Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway
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Authors : Lee et al., Proceedings of the Nation Academy of Sciences of the USA
2017-07 - Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
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Authors : Maliniemi et al., Oncoimmunology
2017-02
