Affinity & specificity of Xanthurenic acid polyclonal antibody
Competitive ELISA demonstrates that low amounts of Xanthurenic acid conjugate are required to abolish antigen-antibody reaction (high affinity), while rising concentrations of Kynurenic acid conjugate do not affect reaction (high specificity).
Xanthurenic acid polyclonal antibody
Ref: IS1014
This is the first and only rabbit polyclonal antibody to Xanthurenic acid available for research use. Proved to be highly affine and specific competitive ELISA, our anti-xanthurenic acid pAb is currently undergoing validation for IHC use.
| Clonality | Polyclonal |
| Host | Rabbit (see anti-XA mouse mAb) |
| Applications | IHC / IF |
| Specie reactivity | Reacts with all species |
| References | Roussel et al, Neuroscience, 2016 |
| Format | 50µL |
| Shipping info : | 75.00€ , 4 days |
| Product information | Protocols | References | Technical support | Reviews |
Product overview
| Product name | Xanthurenic acid polyclonal antibody |
| Synonyms |
Anti-Xanthurenic acid polyclonal antibody 8-Hydroxy-4-oxo-1H-quinoline-2-carboxylic acid polyclonal antibody Xanthuric acid polyclonal antibody Xanthurenate polyclonal antibody 8-Hydroxykynurenic acid polyclonal antibody |
| Immunogen | Conjugated Xanthurenic acid |
| Specificity | When tested in competitive ELISA, the anti-conjugated Xanthurenic acid antibody did not display any significant cross-reactivity with analog Kynurenic acid conjugate. |
| Lot number |
140801 |
Reconstitution & storage
| Form |
Liquid |
| Purity | Purified anti-serum |
| Storage | Store at 4°C |
| Storage buffer |
Before use, vial should be resuspended in 50 µL of ultrapure water. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Material safety datasheet | Download MSDS |
Protocols
| Immunohistochemistry (IHC) |
Optimal working conditions must be determined by the end-user. |
| Immunofluorescence (IF) |
Optimal working conditions must be determined by the end-user. |
| Restrictions | For research use only |
References
- Product citation : Roussel et al. Xanthurenic acid is localized in neurons in the central nervous system. Neuroscience. 2016 Aug 4
Selected publications on Xanthurenic acid:
- Neale SA, Copeland CS, Salt TE. Effect of VGLUT inhibitors on glutamatergic synaptic transmission in the rodent hippocampus and prefrontal cortex.Neurochem Int. 2013 Oct 10. pii: S0197-0186(13)00250-7. doi: 10.1016/j.neuint.2013.10.001. [Epub ahead of print]
- Neale SA et al. Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology. 2013 May;38(6):1060-7. doi: 10.1038/npp.2013.4. Epub 2013 Jan 7.
- Copeland CS1, Neale SA, Salt TE. Actions of Xanthurenic acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus.Neuropharmacology. 2013 Mar;66:133-42. doi: 10.1016/j.neuropharm.2012.03.009. Epub 2012 Apr 2.
- Taleb O et al. Xanthurenic acid binds to neuronal G-protein-coupled receptors that secondarily activate cationic channels in the cell line NCB-20.PLoS One. 2012;7(11):e48553. doi: 10.1371/journal.pone.0048553. Epub 2012 Nov 6.
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