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Affinity & specificity of anti-Anthranilic acid rabbit polyclonal antibodyCompetitive ELISA demonstrates that relatively low amounts of Anthranilic acid conjugate are required to abolish antigen-antibody reaction (moderate affinity), while rising concentrations of 3-HydroxyAnthranilic acid (3-HAA) conjugate do not affect reaction (high specificity).
3-Hydroxy-Anthranilic acidTryptophan catabolism can be initiated by either indoleamine 2,3 dioxygenase 1 and 2 (IDO1 and IDO2) or the tryptophan 2,3 dioxygenase 2 (TDO2) to produce a series of catabolites collectively known as kynurenines. This pathway has been extensively studied for its immune regulatory functions. The production of 3-hydroxy-Anthranilic acid (3HAA) is thought to play a key role in this phenomenon, with PDK1 being the only molecular target identified. Also, 3HAA has been shown to exert anti-inflammatory effects when administered in an experimental model of multiple sclerosis mice (EAE).
Key features
| Clonality | Polyclonal antibody |
| Host | Rabbit |
| Reactivity | Reacts with all species |
| Eligible samples | Cell culture, tissue sections, whole mounts |
| Staining procedure | Perform heat antigen retrieval (pH=6) before standard IHF/IF staining |
| Format | 50µL |
Frequently asked questions
3-Hydroxyanthranilic acid antibody – Rabbit Polyclonal
This is the first and only anti-3-Hydroxy-Anthranilic acid (3-HAA) rabbit polyclonal antibody available for research use. Confirmed to be highly specific and affine by competitive ELISA, the antibody is currently being validated for IHC and IF use.
€449
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IS1008
3-Hydroxyanthranilic acid antibody – Rabbit Polyclonal
3-HydroxyAnthranilic acid pAb – Purified polyclonal antibody for research use only (liquid 50µL)
Specifications
| Product name | 3-Hydroxyanthranilic acid rabbit polyclonal antibody |
| Synonyms | Anti-3-Hydroxy-Anthranilic acid polyclonal antibody
2-Amino-3-hydroxybenzoic acid polyclonal antibody 3-OH-Anthranilic acid polyclonal antibody 3-hydroxanthranilate polyclonal antibody 3-OHAA polyclonal antibody 3-HAA polyclonal antibody |
| Immunogen | Conjugated 3-Hydroxyanthranilic acid |
| Specificity | When tested by competitive ELISA, the anti- 3-HydroxyAnthranilic acid polyclonal antibody did not show any significant cross reactivity with Anthranilic acid or quinolinic acid conjugates |
| Volume | 50 µL |
| Form | Liquid |
| Purity | Purified anti-serum |
Instructions
| Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Immunocytochemistry (ICC) |
Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating staining protocol. |
| Immunohistochemistry (IHC) | Dilute at 1:100-1:1000 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate with fluorescent secondary antibody conjugate |
| Immunofluorescence (IF) | Dilute at 1:100-1:1000 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate with fluorescent secondary antibody conjugate |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
