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Quinaldic acid detection by IHC in human brainImmunohistochemical analysis of human caudate putamen reveals Quinaldic acid accumulation in the cytoplasm of glial cells. Paraffin-embedded tissue was subjected to pH=6 antigen retrieval followed by overnight incubaton with primary anti-Quinaldic antibody (dilution 1/1000). After incubation with polymer conjugated secondary Ab, staining visualization was performed with DAB.
Quinaldic acid detection by IF in human brainQuinaldic acid visualization by immunofluorescence in human caudate putamen. Staining illustrates cytoplasmic accumulation of Quinaldic acid in glial cells. Paraffin-embedded tissue section was subjected to pH=6.
Affinity & Specificity of anti-Quinaldic acid antibodyCompetitive ELISA demonstrates that moderate amounts of Quinaldic acid conjugate are required to abolish antigen-antibody reaction (satisfying affinity), while rising concentrations of Kynurenic and Xanthurenic acid conjugates do not affect the reaction (high specificity).
Quinaldic acid antibodyDespite growing interest on the role of kynurenines in immune regulation and neurotransmission, very few publications address the biological activity of Quinaldic acid, the direct by-product of neuroprotective kynurenic acid. In the 1970's, Quinaldic acid was described as a key regulator of glycemia. More recently, this kynurenine metabolite was found to be associated with hepatitis B virus-related hepatocellular carcinoma.
Key features
| Clonality | Monoclonal antibody (clone 5A4-H10) |
| Host | Mouse |
| Reactivity | Reacts with all species |
| Tested samples | Human tissue sections (FFPE brain tissues) |
| Staining procedure | Perform heat antigen retrieval (pH=6) before standard IHF/IF staining |
| Format | 50µL (approx. 40 tissue sections) |
Frequently asked questions
Quinaldic acid Antibody – Mouse Monoclonal
Our anti-Quinaldic acid antibody is the only primary antibody available to date to stain for quinaldic acid. This mouse monoclonal antibody was validated by our team for immunohistochemistry (IHC) and immufluorescence (IF) in paraffin-embedded tissues from human caudate-putamen region.
€449
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IS004
Quinaldic acid Antibody – Mouse Monoclonal
Anti-Quinaldic acid mAb – Purified monoclonal antibody for research use only (liquid 50µL)
Specifications
| Product name | Quinaldic acid antibody |
| Synonyms | 2-Quinolinecarboxylic acid antibody Quinolin-2-carboxylate acid antibody |
| Immunogen | Conjugated Quinaldic acid |
| Isotype |
IgG1 k chain |
| Clone |
Clone 5A4-H10 |
| Specificity | When tested in competitive ELISA, the anti-Quinaldic acid antibody did not show any significant cross reactivity with Kynurenic and Xanthurenic acid conjugates |
| Volume | 50 µL |
| Form | Liquid |
| Purity | Purified IgG |
Instructions
| Storage |
Store at +4°C for short term (6 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Immunohistochemistry (IHC) | Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
| Immunofluorescence (IF) |
Dilute at 1:100-1:1000 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate with fluorescent dyes conjugated secondary antibody |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
