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Xanthurenic acid in mouse brain tissue sectionsPublished by Roussel et al., in 2016. Staining in mouse cortical tissues sections evidences the presence of Xanthurenic acid in cortical neurons (bodies and dendrites), and its absence from axons.
Xanthurenic acid (XA)Xanthurenic acid is a downstream metabolite of the kynurenine pathway, synthesized from 3-hydroxy-Kynurenine. Xanthurenic acid is know for its specific role in a signaling cascade involved in mosquitoes' gamete maturation. Very few data is available on the role of XA in mammals. Recently, Xanthurenic acid was shown to bind GPCRs. An agonist action of the metabolite on group II metabotropic glutamate receptor has also been proposed.
Affinity & specificity of Xanthurenic acid polyclonal antibodyCompetitive ELISA demonstrates that low amounts of Xanthurenic acid conjugate are required to abolish antigen-antibody reaction (high affinity), while rising concentrations of Kynurenic acid conjugate do not affect reaction (high specificity).
Key features
| Clonality | Polyclonal antibody |
| Host | Rabbit |
| Reactivity | Reacts with all species |
| Tested samples | Rodent primary neurons & brain tissues |
| Staining procedure | Perform heat antigen retrieval (pH=7) before standard IHF/IF staining |
| Format | 50µL |
Frequently asked questions
Xanthurenic acid Antibody – Rabbit Polyclonal
IS1014 was the first anti-Xanthurenic acid cited in the literature, by Roussel et al., in 2016. In this paper, this highly affine rabbit pAb was used to label Xanthurenic acid in mouse brain tissue sections and rat primary neurons.
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IS1014
Xanthurenic acid Antibody – Rabbit Polyclonal
Anti-Xanthurenic acid pAb – Purified polyclonal antibody for research use only (liquid 50µL)
Specifications
| Product name | Xanthurenic acid polyclonal antibody |
| Synonyms | Anti-Xanthurenic acid polyclonal antibody
8-Hydroxy-4-oxo-1H-quinoline-2-carboxylic acid polyclonal antibody Xanthuric acid polyclonal antibody Xanthurenate polyclonal antibody 8-Hydroxykynurenic acid polyclonal antibody |
| Immunogen | Conjugated Xanthurenic acid |
| Specificity | When tested in competitive ELISA, the anti-conjugated Xanthurenic acid antibody did not display any significant cross-reactivity with analog Kynurenic acid conjugate |
| Volume | 50 µL |
| Form | Liquid |
| Purity | Purified anti-serum |
Instructions
| Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Immunohistochemistry (IHC) | Dilute at 1:100-1:1000. Perform heat antigen retrieval (pH=7) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
