Our range of ELISA kits for quantifying tryptophan metabolites welcomes a new addition: Melatonin. This highly sensitive ELISA kit enables the measurement of melatonin levels in plasma and serum samples both during daytime and nighttime.

Primarily synthesized from Serotonin in the pineal gland during nighttime, Melatonin is then released in the bloodstream. During the day, Melatonin concentrations in the blood range from 0 to 20 pg/mL. They peak at night, reaching 40 to 100 pg/mL. With a limit of detection of 1.6 pg/ml, and a range of 0/3 to 300 pg/ml, our Melatonin ELISA kit is thus suitable for most applications.

Obviously of interest for the study of circadian rhythm disorders, the measurement of Melatonin concentrations in blood is relevant in other scientific areas:

• Aging: Melatonin secretion progressively declines with age. Research suggests that melatonin have protective effects against aging and its associated symptoms, including cardiovascular and neurodegenerative disorders.
• Mood disorders: Melatonin secretion can be altered in depressive and bipolar disorders, affecting the onset, duration, and offset of synthesis.
• Reproductive health: Melatonin levels influence menstrual cycles, fertility, and fetal development during pregnancy.
• Immuno-Oncology: Melatonin displays anti-cancer effects by modulating the immune system, acting on various immune cells within the tumor microenvironment (T cells, Tregs, NK cells, and macrophages).
• Metabolic Disorders: Low plasma concentrations of melatonin are often found in diabetes and obesity. The hormone has shown beneficial effects on metabolic, inflammatory, and neuropsychiatric symptoms.

Learn more about our Melatonin ELISA kit