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D-Serine imaging in adult mouse frontal cortexUsing STAINperfect immunostaining kit A and following protocol developped for tissue sections, the anti-D-Serine rabbit polyclonal antibody (Ref: IS1004) revealed the presence of D-Serine postive cells within mouse frontal cortex with a cytoplasmic pattern. The staining was revealed using Alexa Fluor® 488-conjugated secondary antibody and image obtained using confocal imaging.
Affinity & specificity of anti-D-Serine antibodyCompetitive ELISA demonstrates that low amount of D-Serine conjugate is required to abolish antigen recognition by the antibody (high affinity), while rising concentrations of L-Serine or D-Threonine conjugates do not affect this reaction (high specificity).
D-SerineSynthesized from L-Serine in the mammalian brain by the serine racemase enzyme, D-Serine is mainly expressed in the forebrain. Known as a potent co-agonist of the NMDA receptor, D-serine acts both as a gliotransmitter and neurotransmitter, playing a key role in cognition, memory, as well as in the regulation of mood. Elevated levels of D-Serine were recently found in the spinal cord of ALS models and patients, suggesting that the metabolite contributes to motor neuron degeneration. D-Serine production was also observed in peripheral organs, independently of SR expression.
Key features
| Clonality | Polyclonal antibody |
| Host | Rabbit |
| Reactivity | Reacts with all species |
| Tested samples | Rodent tissue sections |
| Staining procedure | STAINperfect immunostaining kit A (protocols for cell cultures, whole mounts, tissue sections) |
| Format | 50µL (approx. 40 tissue sections) |
Frequently asked questions
D-Serine Antibody – Rabbit Polyclonal
The anti-D-Serine antibody IS1004 is the first and only antibody validated for immunofluorescence (IF) applications to date. When paired with the STAINperfect immunostaining kit A, this rabbit polyclonal antibody enables clear visualization of D-Serine in cell cultures, tissue sections, and whole mounts. Our team successfully used IS1004 to detect D-Serine in mouse brain tissue sections.
€449
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IS1004
D-Serine Antibody – Rabbit Polyclonal
Anti-D-serine pAb – Purified polyclonal antibody for research use only (liquid 50µL)
Specifications
| Product name | D-Serine antibody – Rabbit Polyclonal Antibody |
| Synonyms | Anti-D-Serine antibody Anti (R)-Serine antibody |
| Immunogen | Conjugated D-Serine |
| Specificity | When tested in competitive ELISA, the anti-conjugated D-Serine antibody did not show any significant cross reactivity with D-Serine analogs, including L-Serine and D-Threonine |
| Volume | 50 µL |
| Form | Liquid |
| Purity | Purified anti-serum |
Instructions
| Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Immunofluorescence (IF) |
Dilute antibody with the antibody diluent provided in the STAINperfect immunostaining kit A. Use at 1/250 -1/1000 dilution. Follow the STAINperfect protocol suited to your sample (Cell cultures, Whole mounts, Tissue sections) |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
