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Kynurenic acid detection in human caudate putamen by IHCImmunohistochemistry (IHC) reveals kynurenic acid accumulation in the cytoplasm of glial cells in human caudate putamen. Paraffin-embedded brain tissue section was subjected to pH=6 antigen retrieval followed by overnight incubation with the primary anti-kynurenic acid polyclonal antibody (dilution 1/2000). After incubation with polymer-conjugated secondary Ab, DAB was used to visualize the staining.
Kynurenic acidAerobic L-tryptophan degradation via the kynurenine pathway produces a range of neuroactive metabolites, including endogenous neurotoxin quinolinic acid and neuroprotective kynurenic acid. Kynurenic acid indeed possesses several molecular targets with antagonistic activities on the NMDA receptor and the a7-nicotinic cholinoceptor (a7NR). Recently Kynurenic was also described to activate the orphan G-protein-coupled receptor GPR35.
Affinity & specificity of the Kynurenic acid polyclonal antibodyCompetitive ELISA highlights that low amounts of conjugated Kynurenic acid are required to abolish antigen-antibody reaction (high affinity), while rising concentrations of analog conjugates (Quinaldic and Xanthurenic acid) affect only to a lesser extent the reaction (high specificity).
Key features
| Clonality | Polyclonal antibody |
| Host | Rabbit |
| Reactivity | Reacts with all species |
| Tested samples | Human FFPE brain and lung tissues |
| Staining procedure | Perform heat antigen retrieval (pH=6) before standard IHF/IF staining |
| Format | 50µL |
Frequently asked questions
Kynurenic acid Antibody – Rabbit Polyclonal
The anti-kynurenic acid (KYNA) rabbit polyclonal antibody IS1011 was successfully validated for immunohistochemistry (IHC) on human paraffin-embedded brain tissues. Optimal staining was achieved at a 1:2000 dilution, with a single vial sufficient for approximately 400 stainings.
€ 449
94 in stock
| Save with quantity discounts | Unit price after discount |
|---|---|
| 3 to 5 antibodies (any reference) | € 399 |
| 6+ antibodies (any reference) | € 379 |
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IS1011
Kynurenic acid Antibody – Rabbit Polyclonal
Anti-Kynurenic acid pAb – Purified polyclonal antibody for research use only (liquid 50µL)
Specifications
| Product name | Kynurenic acid polyclonal antibody |
| Synonyms | Kinurenic acid polyclonal antibody
4-Hydroxyquinoline-2-carboxylic acid polyclonal antibody KYNA polyclonal antibody |
| Immunogen | Conjugated kynurenic acid |
| Specificity | When tested in competitive ELISA, the anti-Kynurenic polyclonal antibody did not show any significant cross reactivity with Quinaldic and Xanthurenic conjugates |
| Volume | 50 µL |
| Form | Liquid |
| Purity | Purified anti-serum |
Instructions
| Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Immunohistochemistry (IHC) | Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
