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Immunofluorescence imaging of L-Serine in mouse brainstemMouse brainstem (E13.5) immunostaining of soma of L-Serine cells after whole mount processing using STAINPerfect immunostaining kit A. Secondary antibody (goat anti-rabbit Alexa Fluor® 488) was used and picture was acquired by confocal imaging.
Staining of L-Serine and GABA positive neurons in mouse primary cortical culturePrimary mouse cortical neurons were stained using anti-L-Serine (green) polyclonal rabbit antibody (IS1003) and anti-GABA (red)chicken polyclonal antibody (IS1036) using the STAINperfect immunostaining kit A and according to the protocol for cell culture. Fluorescent conjugated secondary antibodies were used and picture obtained by confocal imaging. Co-immunostaining appears in yellow.
Affinity & specificity of anti-L-Serine antibodyCompetitive ELISA demonstrates that low amounts of L-Serine conjugate are required to abolish antigen-antibody reaction (high affinity), while rising concentrations of D-Serine and L-Threonine conjugates do not affect reaction (high specificity).
L-serine AbL-Serine is a non-essential amino acid, which can be derived from dietary intake, from the glycolytic intermediate 3-phospho-glycerate, from glycine or by protein and phospholipid degradation. Serving in key metabolic pathways, including gluconeogenesis, cystathionine formation, gluthathione synthesis and phospholipid synthesis, L-Serine plays a central role in cell proliferation. In the CNS, L-Serine is predominantly synthesized in astrocytes. Either converted into its enantiomer D-Serine or into glycine, L-Serine contributes to the regulation of NMDA receptor activity. Abnormal L-Serine synthesis has been found to be associated with psychatric disorders and severe neurological disfunctions.
Key features
| Clonality | Polyclonal antibody |
| Host | Rabbit |
| Reactivity | Reacts with all species |
| Tested samples | Rodent primary neurons and brain tissues |
| Staining procedure | STAINperfect immunostaining kit A (protocols for cell cultures, whole mounts, tissue sections) |
| Format | 50µL (approx. 40 tissue sections) |
Frequently asked questions
L-Serine Antibody – Rabbit Polyclonal
The anti-L-Serine antibody IS1003 is the first and only antibody available specifically for L-Serine detection. When paired with the STAINperfect immunostaining kit A, this rabbit polyclonal antibody enables clear visualization of L-Serine in cell cultures, tissue sections, and whole mounts. Our team successfully employed IS1003 to detect L-Serine in mouse primary neurons and brainstem tissues.
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IS1003
L-Serine Antibody – Rabbit Polyclonal
Anti-L-Serine pAb – Purified polyclonal antibody for research use only (liquid 50µL)
Specifications
| Product name | L-Serine antibody – Rabbit pAb |
| Synonyms | Anti-L-Serine acid antibody Anti-(S)-2-amino-3-hydroxypropionic acid antibody |
| Immunogen | Conjugated L-Serine |
| Specificity | When tested in competitive ELISA, the anti-conjugated L-Serine antibody did not show any significant cross reactivity with L-Serine analogs, including D-Serine and L-Threonine conjugates |
| Volume | 50 µL |
| Form | Liquid |
| Purity | Purified anti-serum |
Instructions
| Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Immunofluorescence (IF) |
Dilute antibody with the antibody diluent provided in the STAINperfect immunostaining kit A. Use at 1/250 -1/1000 dilution. Follow the STAINperfect protocol suited to your sample (Cell cultures, Whole mounts, Tissue sections) |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
