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Quinolinic acid detection in human parkinson’s brainImmunohistochemistry (IHC) reveals the presence of Quinolinic acid in glial cells in human parkinsonian midbrain tissue. Paraffin-embedded tissue section was subjected to pH=9 antigen retrieval followed by overnight incubation with primary anti-quinolinic acid polyclonal antibody (dilution 1/1000). After incubation with polymer-conjugated secondary Ab, DAB was used to visualize the staining.
Affinity & specificity of anti-Quinolinic polyclonal antibodyCompetitive ELISA highlights that low amounts of conjugated Quinolinic acid conjugate are required to abolish antigen-antibody reaction (high affinity), while rising concentrations of analog conjugates (Picolinic and Anthranilic acids) do not affect the reaction (high specificity).
Quinolinic acidTryptophan catabolism along the kynurenine pathway produces neuroactive metabolites, with prototypical neurotoxin Quinolinic acid as a 'chef de file'. Known to be involved in a wide range of neurodegenerative diseases (Amyotrophic lateral sclerosis, Alzheimer's & Parkinson's diseases, ...) as well as psychiatric disorders (depression, schizophrenia, ...), Quinolinic acid induces neuronal damage. Activation of the NMDA-receptor, oxidative stress induction or mitochondrial dysfunction could explain quinolinic acid-induced neurotoxicity.
Key features
| Clonality | Polyclonal antibody |
| Host | Rabbit |
| Reactivity | Reacts with all species |
| Tested samples | Human FFPE brain and lung tissues |
| Staining procedure | Perform heat antigen retrieval (pH=9) before standard IHF/IF staining |
| Format | 50µL |
Frequently asked questions
Quinolinic acid Antibody – Rabbit Polyclonal
Validated for immunohistochemical analysis in paraffin-embedded human parkinsonian brain specimens, this anti-Quinolinic acid (QUIN) rabbit polyclonal antibody was recently employed in scientific publications to confirm the presence of Quinolinic acid in FFPE brain and lung tissues using both immunohistochemistry (IHC) and immunohistofluorescence (IHF).
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IS1010
Quinolinic acid Antibody – Rabbit Polyclonal
Quinolinic acid pAb – Purified polyclonal antibody for research use only (liquid 50µL)
Specifications
| Product name | Quinolinic acid polyclonal antibody |
| Synonyms | Pyridine-2,3-dicarboxylic acid polyclonal antibody
Anti-quinolinate polyclonal antibody Anti-QUIN polyclonal antibody |
| Immunogen | Conjugated quinolinic acid |
| Specificity | When tested in competitive ELISA, the anti-Quinolinic acid polyclonal antibody did not show any significant cross reactivity with Picolinic and anthranilic acids conjugates |
| Volume | 50 µL |
| Form | Liquid |
| Purity | Purified anti-serum |
Instructions
| Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Immunohistochemistry (IHC) | Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=9) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
