L-Kynurenine ELISA kit
High Sensitivity

Ref: BA-E-2200
Kynurenine pathwayTryptophan metabolismDiagnostic ELISA kits (IVD)Research ELISA kits (RUO)ELISA
DatasheetMSDSIVD Protocol RUO Protocol

The L-Kynurenine ELISA is an easy-to-use assay tailored for the quantification of Kynurenine across large series of samples. Optimized for the analysis of biological fluids (plasma, cell culture supernatant, serum…), the KYN ELISA features a lower limit of detection at 45.7ng/ml and a minimal sample volume of 20µl, thus allowing longitudinal studies in mice.

Sample type Plasma, serum, cell culture supernatant
Capacity 96 tests
Sensitivity < 45.7ng/ml
Range 100 – 10000ng/ml
Assay time Sample acylation 90 min, ELISA overnight
Reactivity Reacts with all species
References Cited in 70 papers
Size

1 x 96 wells

Regulatory status

In Vitro Diagnostics (EU), Research Use Only

499.00

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They published with this product  see papers

University of Florence
University of Antwerp
First Affiliated Hospital of Sun Yat-sen University
Medical University of Vienna
MD Anderson Cancer Center
Johns Hopkins University School f Medicine

Product overview

Product name L-Kynurenine ELISA kit
Description Enzyme immunoassay (ELISA) for the quantitative determination of L-Kynurenine in biological fluids and cell supernatant
Format 96-well plate
Samples Plasma, serum, cell culture supernatant
Minimal sample volume 20µL
Reactivity Reacts with all species
Standard range 0/100 – 10000ng/ml
Sensitivity

< 47.5ng/ml

Specificity No significant cross-reactivity was observed with L-Kynurenine analogs such as L-Tryptophan, 3-Hydroxy-DL-Kynurenine, 5-Hydroxy-DL-Tryptophan, Tyrosine, Serotonin, Phenylalanin, L-Asparagine and Kynurenic acid
Assay time Sample acylation 90 min and ELISA overnight
Storage Store at 2-8°C for to 6 months
Datasheets Instructions for use, Material Safety Datasheet

 

Sample collection & storage Plasma/Serum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands. Store smaples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months)
Sample preparation Sample acylation (90 min)
ELISA L-Kynurenine antiserum overnight incubation, revelation and read steps (1h)
Detailed protocol RUO: Download instructions for use

IVD:  Download instructions for use

 

Product citations

  • Benzo[a]pyrene exposure prevents high fat diet-induced obesity in the 4T1 model of mammary carcinoma
    Check article
    Authors : R Gonzalez-Ponsand & JJ Bernard, Front Oncol.
    2024-09
  • Continuous theta burst stimulation for bipolar depression: A multicenter, double-blind randomized controlled study exploring treatment efficacy and predictive potential of kynurenine metabolites
    Check the article
    Authors : Dellink et al., Journal of Affective Disorders
    2024-09
  • Transcriptomic evidence of immune modulation in subjects with chronic Trypanosoma cruzi infection
    Check article
    Authors : Ros-Lucas et al., J Infect Dis.
    2024-08
  • Surface-Enhanced Raman Scattering Monitoring of Tryptophan Dynamics in 3D Pancreatic Tumor Models
    Check the article
    Authors : Valera et al., ACS Sensors
    2024-07
  • Induction of indoleamine 2,3-dioxygenase 1 expression in neurons of the central nervous system through inhibition of histone deacetylases blocks the progression of experimental autoimmune encephalomyelitis
    Check the article
    Authors : Kim CE et al., Int Immunopharmacol.
    2024-06
  • VEEV TC-83 Triggers Dysregulation of the Tryptophan–Kynurenine Pathway in the Central Nervous System That Correlates with Cognitive Impairment in Tg2576 Mice
    Check the article
    Authors : Fongsaran C. et al., Pathogens
    2024-05
  • Unveiling the Role of Tryptophan 2,3-Dioxygenase in the Angiogenic Process
    Check the article
    Authors : Cecchi M. et al., Pharmaceuticals
    2024-04
  • Effects of a flavonoid-rich blackcurrant beverage on markers of the gut-brain axis in healthy females: Secondary findings from a 4-week randomized crossover control trial
    Check the article
    Authors : Gillies et al., Current Developments in Nutrition
    2024-04
  • Derangements of immunological proteins in HIV-associated diffuse large B-cell lymphoma: the frequency and prognostic impact
    Check the article
    Authors : Vaughan et al., Front. Cell. Infect. Microbiol.
    2024-04
  • Downregulation of Serotonergic System Components in an Experimentally Induced Cryptorchidism in Rabbits
    Check the article
    Authors : Jiménez-Trejo F. et al., Int. J. Mol. Sci.
    2024-03
  • PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma
    Check the article
    Authors : Shu G. et al, Cancer Res
    2024-02
  • The dangerous “West Coast Swing” by hyperglycaemia and chronic stress in the mouse hippocampus: Role of kynurenine catabolism
    Check the article
    Authors : Gliozzi M et al., Pharmacological Research
    2024-01
  • Camptothesome-based combination nanotherapeutic regimen for improved colorectal cancer immunochemotherapy
    Check the article
    Authors : Wang Z. et al., Biomaterials
    2024-01
  • Sphingomyelin-derived nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance metastatic and post-surgical melanoma immunotherapy
    Check the article
    Authors : Wang et al., Nature Communications
    2023-11
  • Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging
    Check the article
    Authors : Mougin et al., Foods
    2023-11
  • An open label randomized controlled trial of atorvastatin versus aspirin in elite controllers and antiretroviral-treated people with HIV
    Check the article
    Authors : Mystakeli et al., AIDS
    2023-10
  • Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress
    Check article
    Authors : Letenneur et al., Nutrients
    2023-10
  • Hypomethylation-induced regulatory programs in T cells unveiled by transcriptomic analyses
    Check the article
    Authors : Lysandrou et al., Frontiers in Immunology
    2023-09
  • Pathogenetic associations of anti-ribosomal P protein antibody titres and their subclasses in patients with systemic lupus erythematosus
    Check the article 
    Authors : Kaneko et al., Rheumatology
    2023-08
  • Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study
    Check the article
    Authors : Onning et al., Nutrients
    2023-08
  • Effects of Supplementation with the Standardized Extract of Saffron (affron®) on the Kynurenine Pathway and Melatonin Synthesis in Rats
    Check the article
    Authors : Munoz et al., Antioxydants
    2023-07
  • Advances in kynurenine analysis
    Check the article
    Authors : Mrstna et al., Clinica Chimica Acta
    2023-07
  • Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
    Check the article
    Authors : Dongen et al., bioRxiv
    2023-07
  • Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials
    Check article
    Authors : Girithar et al., British Journal of Cancer
    2023-04
  • Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions
    Check the article
    Authors : Cremone et al., Biomedicines
    2023-04
  • Tryptophan degradation enzymes expression in the placenta and the Kynurenine/Tryptophan ratio in maternal plasma after elective cesarean section
    Check the article
    Authors : Silvano et al., Journal of Reproductive Immunology
    2023-02
  • Citrulline and kynurenine to tryptophan ratio: potential EED (environmental enteric dysfunction) biomarkers in acute watery diarrhea among children in Bangladesh
    Check the article
    Authors : Das et al., Scientific Reports
    2023-01
  • Priming Mesenchymal Stem/Stromal Cells with a Combination of a Low Dose of IFN- and Bor_tezomib Results in Potent Suppression of Pathogenic Th17 Immunity Through the IDO1-AHR Axis
    Check the article
    Authors : Park et al., Stem Cells
    2022-10
  • Tryptophan degradation enzymes and Angiotensin (1−7) expression in human placenta
    Check the article
    Authors : Silvano et al., Journal of Reproductive Immunology
    2022-09
  • IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma
    Check the article
    Authors : Struckmeier et al., Journal of Cancer Reasearch & Clinical Oncology
    2022-08
  • Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
    Check the article
    Authors : Sugisawa et al., Cell reports
    2022-03
  • Tryptophan Metabolism Is Associated with BMI and Adipose Tissue Mass and Linked to Metabolic Disease in Pediatric Obesity
    Check the article
    Authors : Lischka et al, Nutrients
    2022-01
  • Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo
    Check the article
    Authors : Siska et al., eBioMedicine
    2021-12
  • Cancer-associated fibroblasts educate normal fibroblaststo facilitate cancer cell spreading and T-cell suppression
    Check the article
    Authors : Itoh et al., Molecular Oncology
    2021-11
  • Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma
    Check the article
    Authors : Pospíšková et al., Pteridines
    2021-11
  • Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway
    Check the article
    Authors : Kim et al., Oncoimmunology
    2021-11
  • Apathy is not associated with a panel of biomarkers in older adults with HIV disease
    Check the article
    Authors : Wood et al., Journal of psychosomatic research
    2021-11
  • Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives
    Check the article
    Authors : Sadok et al., Sensors
    2021-10
  • The effects of high-monosaccharide diets on development and biochemical composition of white-eyed mutant strain of house cricket (Acheta domesticus)
    Check the article
    Authors : Francikowski et al., Scientific reports
    2021-10
  • Plasma Kynurenine-to-Tryptophan Ratio, a Highly Sensitive Blood-Based Diagnostic Tool for Tuberculosis in Pregnant Women Living With Human Immunodeficiency Virus (HIV)
    Check the article
    Authors : Adu-Gyamfi et al., Clinical infectious Diseases
    2021-10
  • The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation
    Check the article
    Authors : Eleftheriadis et al., Biomolecules
    2021-10
  • Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
    Check the article
    Authors : Wang et al., Frontiers in microbiology
    2021-06
  • STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer
    Check the article
    Authors : Lee et al., Journal of Immunotherapy of Cancer
    2021-06
  • Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza
    Check the article
    Authors : Jung Cho et al., European Respiratory Journal
    2021-05
  • Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways
    Check the article
    Authors : MacDowell et al., Frontiers in Pharmacology
    2021-05
  • Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells
    Check the article
    Authors : Eleftheriadis et al., Molecular Medicine Reports
    2021-04
  • IDO1-mediated Trp-kynurenine-AhR signal activation induces stemness and tumor dormancy in oral squamous cell carcinomas
    Check the article
    Authors : Anzai et al., Oral Science International
    2021-04
  • Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
    Check the article
    Authors : Bekki et al., PloS one
    2020-10
  • Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans
    Check the article
    Authors : Baumgartner et al., Journal of internal medicine
    2020-08
  • Diagnostic accuracy of plasma kynurenine/tryptophan ratio, measured by enzyme-linked immunosorbent assay, for pulmonary tuberculosis
    Check the article
    Authors : Adu-Gyamfi et al., International journal of infectious diseases
    2020-08
  • Effect of repetitive transcranial magnetic stimulation on the kynurenine pathway in stroke patients
    Check the article
    Authors : Masachika et al., Clinical neuroscience
    2020-06
  • Evaluating the potential role of tryptophan in calf milk replacers to facilitate weaning
    Check the article
    Authors : Yeste et al., Journal of Dairy Science
    2020-05
  • Prognostic value of indoleamine 2,3 dioxygenase in patients with higher-risk myelodysplastic syndromes treated with azacytidine
    Check the article
    Authors : Müller-Thomas et al., British journal of haematology
    2020-04
  • IDO Targeting in Sarcoma: Biological and Clinical Implications
    Check the article
    Authors : Nafia et al., Frontiers in immunology
    2020-03
  • Selective Killing of Activated T Cells by 5- Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
    Check the article
    Authors : Darvekar et al., Cancers
    2020-02
  • A highly efficient modality to block the degradation of tryptophan for cancer immunotherapy: locked nucleic acid-modified antisense oligonucleotides to inhibit human indoleamine 2,3-dioxygenase 1/tryptophan 2,3-dioxygenase expression
    Check the article
    Authors : Klar et al., Cancer Immunol Immunother
    2020-01
  • Physical exercise prevents mice from L-Kynurenine-induced depression-like behavior
    Check the article
    Authors : Su et al., Asian Journal of Psychatry
    2019-12
  • Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8 + T-Cell-Dependent Tumor Activity
    Check the article
    Authors : Watanabe et al., Clinical Cancer Research
    2019-11
  • Blood Predictive Biomarkers for Patients With Non-small-cell Lung Cancer Associated With Clinical Response to Nivolumab
    Check the article
    Authors : Agullo-Ortuno et al., Clinical lung cancer
    2019-08
  • Lactobacillus maintains healthy gut mucosa by producing L-Ornithine
    Check the article
    Authors : Qi et al., Communications Biology
    2019-05
  • Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway
    Check the article
    Authors : Allison et al., American Journal of Psycology
    2019-01
  • Traumatic injury leads to inflammation and altered tryptophan metabolism in the juvenile rabbit brain
    Check the article
    Authors : Zhang et al., Journal of Neurotrauma
    2018-09
  • Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice
    Check the article
    Authors : Walker et al., Molecular Psychiatry
    2018-07
  • Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats
    Check the article
    Authors : Martin-Hernandez et al., Molecular Neurobiology
    2018-05
  • Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections
    Check the article
    Authors : Ziklo et al., Frontiers in cellular and infection microbiology
    2018-01
  • In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis
    Check the article
    Authors : Gautam et al., Proceedings of the National Academy of Sciences of the USA
    2018-01
  • Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas: A Phase 2 Clinical Trial
    Check the article
    Authors : Toulmonde et al., JAMA oncology
    2018-01
  • Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway
    Check the article
    Authors : Lee et al., Proceedings of the Nation Academy of Sciences of the USA
    2017-07
  • The peroxyl radical-induced oxidation of Escherichia coli FtsZ and its single tryptophan mutant (Y222W) modifies specific side-chains, generates protein cross-links and affects biological function
    Check the article
    Authors : Escobar-Alvarez et al., Free radical biology & medicine
    2017-07
  • The Functional Relationship Between The Gut Microbiota And Generalized Anxiety Disorder in The Murine Model
    Check the article
    Authors : Perez Guzman et al., Thesis - McMaster University
    2017-06
  • Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
    Check the article
    Authors : Maliniemi et al., Oncoimmunology
    2017-02

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