L-Kynurenine ELISA kit
High Sensitivity

Ref: BA-E-2200
Kynurenine pathwayTryptophan metabolismDiagnostic ELISA kits (IVD)Research ELISA kits (RUO)ELISA
DatasheetMSDSIVD Protocol RUO Protocol

The L-Kynurenine ELISA is an easy-to-use assay tailored for the quantification of Kynurenine across large series of samples. Optimized for the analysis of biological fluids (plasma, cell culture supernatant, serum…), the KYN ELISA features a lower limit of detection at 45.7ng/ml and a minimal sample volume of 20µl, thus allowing longitudinal studies in mice.

Sample typePlasma, serum, cell culture supernatant
Capacity96 tests
Sensitivity< 45.7ng/ml
Range100 – 10000ng/ml
Assay timeSample acylation 90 min, ELISA overnight
ReactivityReacts with all species
ReferencesCited in >50 papers
Size

1 x 96 wells

Regulatory status

In Vitro Diagnostics (EU), Research Use Only

492.00

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Total

492.00

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Product overview

Product nameL-Kynurenine ELISA kit
DescriptionEnzyme immunoassay (ELISA) for the quantitative determination of L-Kynurenine in biological fluids and cell supernatant
Format96-well plate
SamplesPlasma, serum, cell culture supernatant
Minimal sample volume20µL
ReactivityReacts with all species
Standard range0/100 – 10000ng/ml
Sensitivity

< 47.5ng/ml

SpecificityNo significant cross-reactivity was observed with L-Kynurenine analogs such as L-Tryptophan, 3-Hydroxy-DL-Kynurenine, 5-Hydroxy-DL-Tryptophan, Tyrosine, Serotonin, Phenylalanin, L-Asparagine and Kynurenic acid
Assay timeSample acylation 90 min and ELISA overnight
StorageStore at 2-8°C for to 6 months
DatasheetsInstructions for use, Material Safety Datasheet

 

Sample collection & storagePlasma/Serum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands. Store smaples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months)
Sample preparationSample acylation (90 min)
ELISAL-Kynurenine antiserum overnight incubation, revelation and read steps (1h)
Detailed protocolRUO: Download instructions for use

IVD:  Download instructions for use

 

Product citation

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    Authors : Kaneko et al., Rheumatology
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    Authors : Dongen et al., bioRxiv
    2023-07
  • Advances in kynurenine analysis
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    Authors : Mrstna et al., Clinica Chimica Acta
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    Authors : Girithar et al., British Journal of Cancer
    2023-04
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    Authors : Silvano et al., Journal of Reproductive Immunology
    2023-02
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    Authors : Das et al., Scientific Reports
    2023-01
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    Authors : Park et al., Stem Cells
    2022-10
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    Authors : Silvano et al., Journal of Reproductive Immunology
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    Authors : Struckmeier et al., Journal of Cancer Reasearch & Clinical Oncology
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    Authors : Sugisawa et al., Cell reports
    2022-03
  • Tryptophan Metabolism Is Associated with BMI and Adipose Tissue Mass and Linked to Metabolic Disease in Pediatric Obesity
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    Authors : Lischka et al, Nutrients
    2022-01
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    Authors : Siska et al., eBioMedicine
    2021-12
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    Authors : Kim et al., Oncoimmunology
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    Authors : Sadok et al., Sensors
    2021-10
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    Authors : Adu-Gyamfi et al., Clinical infectious Diseases
    2021-10
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    Authors : Wang et al., Frontiers in microbiology
    2021-06
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    Authors : MacDowell et al., Frontiers in Pharmacology
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  • Diagnostic accuracy of plasma kynurenine/tryptophan ratio, measured by enzyme-linked immunosorbent assay, for pulmonary tuberculosis
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  • Effect of repetitive transcranial magnetic stimulation on the kynurenine pathway in stroke patients
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  • Physical exercise prevents mice from L-Kynurenine-induced depression-like behavior
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    Authors : Su et al., Asian Journal of Psychatry
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  • Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway
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    Authors : Allison et al., American Journal of Psycology
    2019-01
  • Traumatic injury leads to inflammation and altered tryptophan metabolism in the juvenile rabbit brain
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    Authors : Zhang et al., Journal of Neurotrauma
    2018-09
  • Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice
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    Authors : Walker et al., Molecular Psychiatry
    2018-07
  • Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats
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    Authors : Martin-Hernandez et al., Molecular Neurobiology
    2018-05
  • Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections
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    Authors : Ziklo et al., Frontiers in cellular and infection microbiology
    2018-01
  • In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis
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    Authors : Gautam et al., Proceedings of the National Academy of Sciences of the USA
    2018-01
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    Authors : Lee et al., Proceedings of the Nation Academy of Sciences of the USA
    2017-07
  • The peroxyl radical-induced oxidation of Escherichia coli FtsZ and its single tryptophan mutant (Y222W) modifies specific side-chains, generates protein cross-links and affects biological function
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    Authors : Escobar-Alvarez et al., Free radical biology & medicine
    2017-07
  • Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
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    2017-02

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