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L-Serine Antibody – Rabbit Polyclonal
Ref: IS1003NeuromediatorsAmino acidsPolyclonal AntibodiesICCIFIHC
+L-Serine immunostaining of mouse brainstem (E13.5)
Mouse brainstem (E13.5) immunostaining of soma of L-Serine cells after whole mount processing using STAINPerfect immunostaining kit A. Secondary antibody (goat anti-rabbit Alexa Fluor® 488) was used and picture was acquired by confocal imaging.
DatasheetMSDS
The rabbit polyclonal antibody IS1003 is directed against conjugated L-Serine. In combination with the STAINperfect immunostaining kit A, this anti-L Serine antibody was used to visualize L-serine (immunofluorescence) in mouse primary neurons & brain stem tissues, and crayfish CNS tissues.
| Clonality | Polyclonal antibody |
| Host | Rabbit |
| Reactivity | Reacts with all species |
| Tested samples | Whole mounts, cell culture, tissue sections |
| Staining procedure | STAINperfect immunostaining kit A |
| Format | 50µL (approx. 40 tissue sections) |
Product overview
| Product name | L-Serine antibody – Rabbit pAb |
| Synonyms | Anti-L-Serine acid antibody Anti-(S)-2-amino-3-hydroxypropionic acid antibody |
| Immunogen | Conjugated L-Serine |
| Specificity | When tested in competitive ELISA, the anti-conjugated L-Serine antibody did not show any significant cross reactivity with L-Serine analogs, including D-Serine and L-Threonine conjugates |
Storage
| Form | Liquid |
| Purity | Purified anti-serum |
| Storage buffer | Store at +4°C for short term (1-2 monts). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Material safety datasheet | Download MSDS |
| IF – Cell cultures, Whole mounts, Tissue sections | Dilute antibody with the antibody diluent provided in the STAINperfect immunostaining kit A. Use at 1/250 -1/1000 dilution. Follow the STAINperfect protocol suited to your sample |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
| Full protocol | Download STAINperfect protocol for L-Serine staining |
| Protocols-at-a-glance |
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| Complete Instructions for Use | Protocol-at-a-glance for cell cultures | Protocol-at-a-glance for whole mounts | Protocol-at-a-glance for tissue sections |
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Selected publications about L-Serine:
- Pollari S et al. Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. Breast Cancer Res Treat. 2011 Jan;125(2):421-30. doi: 10.1007/s10549-010-0848-5. Epub 2010 Mar 30.
- Yang JH et al. Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain. J Biol Chem. 2010 Dec 31;285(53):41380-90. doi: 10.1074/jbc.M110.187443. Epub 2010 Oct 21.
- Tabatabaie L, Klomp LW, Berger R, de Koning TJ. L-serine synthesis in the central nervous system: a review on serine deficiency disorders. Mol Genet Metab. 2010 Mar;99(3):256-62. doi: 10.1016/j.ymgme.2009.10.012. Epub 2009 Oct 25.
