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Quinolinic Acid ELISA kit High Sensitivity, Plasma & SerumQuinolinic acid (QA) is a metabolite produced along the Kynurenine Pathway, which converts the amino acid Tryptophan to NAD+, a cofactor of many enzymatic reactions.
Typical standard curve of Quinolinic acid ELISAExample of standard curve obtained with the QA ELISA Kit. In this competitive ELISA, optical density is inversely correlated with Quinolinic Acid levels.
correlation-data-plate-2-ldn-efs-ng_ml-n-28_961Human serum samples (n=28) were processed for Quinolinic Acid measurement by mean of both QA ELISA kit and liquid chromatography–mass spectrometry (LC/MS). As depicted, results obtained with ELISA and LC/MS are highly correlated (R Squared=0,9954).
quinolinic-acid_kynurenines_1028Quinolinic acid (QA) is a downstream metabolite of the kynurenine pathway, which converts the amino acid tryptophan into nicotinamide adenine dinucleotide (NAD+), a co‑factor for numerous enzymatic reactions. QA is neurotoxic, chiefly through activation of the N‑methyl‑D‑aspartate (NMDA) receptor. Its production in myeloid‑derived cells (e.g., macrophages and microglia) is strongly up‑regulated by inflammatory stress, implicating QA in neuroinflammatory disorders such as Alzheimer’s and Parkinson’s diseases, multiple sclerosis, and amyotrophic lateral sclerosis. Proposed as a biomarker for these conditions, QA also warrants investigation as a surrogate marker in other inflammation‑driven diseases, including cancer and metabolic disorders.
Key features
| Sample type | Serum, Plasma |
| Capacity | 96 tests |
| Sensitivity |
< 6ng/mL |
| Range | 25 – 2000ng/mL |
| Assay time | Sample acylation (120 min), overnight incubation, ELISA revelation & read step (1h) |
| Reactivity | Reacts with all species |
| Application | Research use only |
Frequently asked questions
Quinolinic Acid ELISA kit
The Quinolinic Acid ELISA kit is optimized for sensitive quantification of the neurotoxin quinolinic acid (QA, also known as QUIN) in serum or plasma. This user‑friendly competitive assay works equally well for small pilot studies and high‑throughput projects. It requires only 25 µL of sample per well and is species‑independent, making it suitable for both pre‑clinical and clinical research.
The kit has already been used to measure QA in mouse and human plasma, serum, and cell‑culture supernatants across studies on cancer, cardiovascular disease, and neuroinflammatory conditions such as bipolar disorder, multiple sclerosis, and autism spectrum disorder.
€599
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For questions, protocol recommendations, and troubleshooting, you have direct access to the scientist that developed the antibody or ELISA kit you’re using.
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IS-I-0100R
Quinolinic Acid ELISA kit
Quinolinic acid ELISA kit – Research test for the detection of Quinolinic Acid
Specifications
| Product name | Quinolinic Acid ELISA kit |
| Description | Competitive ELISA kit for the quantitative measurement of Quinolinic Acid levels in serum and plasma samples. For research use only |
| Format | 96-well plate |
| Samples | Serum, Plasma |
| Minimal sample volume | 25µL |
| Reactivity | Reacts with all species |
| Standard range | 25 – 2000ng/mL |
| Sensitivity |
< 6ng/mL |
| Specificity | No significant cross-reactivity was observed with Quinolinic Acid analogs such as Kynurenic acid, Xanthurenic acid, Kynurenine, Picolinic acid, 3-Hydroxy-Anthranilic Acid |
| Assay time | Sample acylation (120min), overnight incubation, ELISA revelation & read step (1h) |
Instructions
| Storage | Store at 2-8°C for to 6 months |
| Sample collection & storage | Serum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands. Plasma (Heparin). Store samples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months) |
| Sample preparation | Sample acylation (120 min) |
| ELISA | Quinolinic acid antiserum overnight incubation, revelation, and read steps (1h) |
