Quinolinic acid Antibody – Mouse Monoclonal
Ref: IS002
Kynurenine pathwayTryptophan metabolismToxinsMonoclonal AntibodiesICCIFIHC
DatasheetMSDS
This mouse monoclonal antibody to Quinolinic acid was validated for IF & IHC in human brain tissues. It was recently used in 3 papers to evidence the role of Quinolinic acid in atherogenesis & glioblastoma.
Clonality | Monoclonal antibody (clone 4E11-G3) |
Host | Mouse |
Valided applications | IHC / IF |
Reactivity | Reacts with all species |
References | Not yet cited to our knowledge Submit content and get a 10% discount! |
Format | 50µL |
References | Cited in 4 papers |
Size | 50µl |
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440.00€
78 in stock
Worldwide shipping
They published with this product see papers
Product overview
Product name | Quinolinic acid antibody |
Synonyms | Pyridine-2,3-dicarboxylic acid antibody
2,3-pyridinedicarboxylic acid antibody 3,4-Pyridinedicarboxylic acid antibody Pyridine-3,4-dicarboxylic acid antibody |
Immunogen | Conjugated quinolinic acid |
Isotype | IgG1 k chain |
Clone | clone 4E11-G3 |
Specificity | When tested in competitive ELISA, the anti-Quinolinic acid antibody did not show any significant cross reactivity with Picolinic and Quinaldic acid conjugates |
Lot number | 240327 |
Expiration date | 2028-03-01 |
Storage
Form | Liquid |
Purity | Purified IgG |
Concentration | 0,5mg/ml |
Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
Material safety datasheet | Download MSDS |
Immunohistochemistry (IHC) | Dilute at 1:100-1:1000. Perform heat antigen retrieval (pH=9) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
Immunofluorescence (IF) | Dilute at 1:50-1:500 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate fluorescent dyes conjugated secondary antibody |
Comments | Optimal working dilutions must be determined by the end-user |
Restrictions | For research use only |
Product citations
- The dangerous “West Coast Swing” by hyperglycaemia and chronic stress in the mouse hippocampus: Role of kynurenine catabolism
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Authors : Gliozzi M et al., Pharmacological Research
2024-01 - Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
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Authors : Dongen et al., bioRxiv
2023-07 - Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis
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Authors : Kesarwani et al., Nature Communications
2023-03 - Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
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Authors : Sugisawa et al., Cell reports
2022-03