Related products
Xanthurenic acid Antibody – Mouse Monoclonal
€449
D-Serine Antibody – Rabbit Polyclonal
€449
Cinnabarinic acid Antibody – Mouse Monoclonal
€449
Xanthurenic acid Antibody – Rabbit Polyclonal
€449
L-Kynurenine Antibody – Rabbit Polyclonal
€449
GABA Antibody – Rabbit Polyclonal
€449
Kynurenic acid detection in human caudate putamen by IHCImmunohistochemistry (IHC) reveals kynurenic acid accumulation in the cytoplasm of glial cells in human caudate putamen. Paraffin-embedded brain tissue section was subjected to pH=6 antigen retrieval followed by overnight incubation with the primary anti-kynurenic acid polyclonal antibody (dilution 1/2000). After incubation with polymer-conjugated secondary Ab, DAB was used to visualize the staining.
Kynurenic acidAerobic L-tryptophan degradation via the kynurenine pathway produces a range of neuroactive metabolites, including endogenous neurotoxin quinolinic acid and neuroprotective kynurenic acid. Kynurenic acid indeed possesses several molecular targets with antagonistic activities on the NMDA receptor and the a7-nicotinic cholinoceptor (a7NR). Recently Kynurenic was also described to activate the orphan G-protein-coupled receptor GPR35.
Affinity & specificity of the Kynurenic acid polyclonal antibodyCompetitive ELISA highlights that low amounts of conjugated Kynurenic acid are required to abolish antigen-antibody reaction (high affinity), while rising concentrations of analog conjugates (Quinaldic and Xanthurenic acid) affect only to a lesser extent the reaction (high specificity).
Key features
| Clonality | Polyclonal antibody |
| Host | Rabbit |
| Reactivity | Reacts with all species |
| Tested samples | Human FFPE brain and lung tissues |
| Staining procedure | Perform heat antigen retrieval (pH=6) before standard IHF/IF staining |
| Format | 50µL |
Frequently asked questions
Kynurenic acid Antibody – Rabbit Polyclonal
The anti-kynurenic acid (KYNA) rabbit polyclonal antibody IS1011 was successfully validated for immunohistochemistry (IHC) on human paraffin-embedded brain tissues. Optimal staining was achieved at a 1:2000 dilution, with a single vial sufficient for approximately 400 stainings.
€449
95 in stock
Pay by online or by purchase order
Pay by credit/debit card or generate a quote at checkout (your products will be sent once you provide us with the purchase order)
Fast Worldwide Shipping with Fedex
We ship your order door-to-door in all countries with FedEx International Priority®.
Worry-free Warranty
Made a mistake ordering ? 30-day free return & refund.
Product damaged during shipping ? Free replacement.
Not getting satisfactory results ? If product did not meet quality standards, customer support offers replacement or refund.
Direct Customer Support
For questions, protocol recommendations, and troubleshooting, you have direct access to the scientist that developed the antibody or ELISA kit you’re using.
Direct customer support is available all business days.
A knowledge base containing protocols, Frequently Asked Questions, and troubleshooting tips is also available online.
They published with this product
You may also like…
L-Tryptophan Antibody – Mouse Monoclonal
€449
Kynurenine/Kynurenic Acid/Quinolinic Acid ELISA pack (3-KYNs ELISA pack)
€1499€1797
L-Kynurenine Antibody – Mouse Monoclonal
€449
Quinolinic acid Antibody – Mouse Monoclonal
€449
IS1011
Kynurenic acid Antibody – Rabbit Polyclonal
Anti-Kynurenic acid pAb – Purified polyclonal antibody for research use only (liquid 50µL)
Specifications
| Product name | Kynurenic acid polyclonal antibody |
| Synonyms | Kinurenic acid polyclonal antibody
4-Hydroxyquinoline-2-carboxylic acid polyclonal antibody KYNA polyclonal antibody |
| Immunogen | Conjugated kynurenic acid |
| Specificity | When tested in competitive ELISA, the anti-Kynurenic polyclonal antibody did not show any significant cross reactivity with Quinaldic and Xanthurenic conjugates |
| Volume | 50 µL |
| Form | Liquid |
| Purity | Purified anti-serum |
Instructions
| Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Immunohistochemistry (IHC) | Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
