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Affinity & specificity of Picolinic acid polyclonal antibodyCompetitive ELISA demonstrates that low amounts of Picolinic acid conjugate are required to abolish antigen-antibody reaction (high affinity), while rising concentrations of Quinolinic acid conjugate do not affect reaction (high specificity).
Picolinic acidPicolinic acid is an isomer of nicotinic acid produced through the degradation of L-Tryptophan along the kynurenine pathway. Mostly studied for its chelating properties in the human body, Picolinic is also known for its role in immune response and neuroprotection. The metabolite, which induces macrophage activation through macrophage inhibitory protein- (MIP-) 1α and MIP-1β, was indeed found to exert antimicrobial and antiviral effects. In the brain, it was demonstrated to protect cholinergic neurons from quinolinic acid-induced neurotoxicity.
Key features
| Clonality | Polyclonal antibody |
| Host | Rabbit |
| Reactivity | Reacts with all species |
| Eligible samples | Cell cultures, Tissue sections |
| Staining procedure | Perform heat antigen retrieval (pH=6) before standard IHF/IF staining |
| Format | 50µL |
Frequently asked questions
Picolinic acid Antibody – Rabbit Polyclonal
This is the first and only anti-Picolinic acid antibody available for research use. Confirmed to be highly specific and affine by competitive ELISA, this rabbit polyclonal antibody is undergoing validation for IHC and IF use.
€449
100 in stock
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IS1015
Picolinic acid Antibody – Rabbit Polyclonal
Anti-Picolinic acid pAb – Purified polyclonal antibody for research use only (liquid 50µL)
Specifications
| Product name | Picolinic acid antibody |
| Synonyms | Pyridine-2-carboxylic acid antibody |
| Immunogen | Conjugated picolinic acid |
| Specificity | When tested in competitive ELISA, the anti-Picolinic acid antibody did not show any significant cross reactivity with analog Quinolinic acid |
| Volume | 50 µL |
| Form | Liquid |
| Purity | Purified anti-serum |
Instructions
| Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Immunocytochemistry (ICC) | Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating staining protocol. |
| Immunohistochemistry (IHC) | Dilute at 1:100-1:1000 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate with fluorescent secondary antibody conjugate. |
| Immunohistofluorescence (IHF) |
Dilute at 1:100-1:1000 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate with fluorescent secondary antibody conjugate |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
