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Quinolinic acid antibody – mouse mAbIS002

Quinolinic acid detection in human midbrain by immunohistofluorescence (IHF)Immunofluorescence staining highlights nuclear exclusion of Quinolinic acid in human midbrain. Paraffin-embedded brain tissue section was subjected to pH=9 antigen retrieval followed by overnight incubation with primary anti-Quinolinic acid antibody (dilution 1/250). After incubation with Alexa-555 conjugated secondary Ab, epifluorescence microscopy (100X) was used to visualize the staining.

Quinolinic acid detection in human midbrain by immunohistochemistry (IHC)Immunohistochemical analysis reveals cytoplasmic presence of Quinolinic acid in human midbrain tissue. Paraffin-embedded tissue section was subjected to pH=9 antigen retrieval followed by overnight incubation with primary anti-quinolinic acid antibody (dilution 1/500). After incubation with polymer-conjugated secondary Ab, DAB was used to visualize the staining.

Anti- Quinolinic acid antibody affinity & specificityCompetitive ELISA demonstrates that low amounts of Quinolinic acid conjugate are required to abolish antigen-antibody reaction (high affinity), while rising concentrations of Picolinic and Quinaldic acid conjugates do not affect the reaction (high specificity).

Quinolinic acidTryptophan catabolism along the kynurenine pathway produces neuroactive metabolites, with prototypical neurotoxin Quinolinic acid as a 'chef de file'. Known to be involved in a wide range of neurodegenerative diseases (Amyotrophic lateral sclerosis, Alzheimer's & Parkinson's diseases, ...) as well as psychiatric disorders (depression, schizophrenia, ...), Quinolinic acid induces neuronal damage. Activation of the NMDA-receptor, oxidative stress induction or mitochondrial dysfunction could explain quinolinic acid-induced neurotoxicity.

Key features

Clonality	Monoclonal antibody (clone 4E11-G3)
Host	Mouse
Reactivity	Reacts with all species
Tested samples	Human tissue sections (brain, tumor tissues), rodent tissues
Staining procedure	Perform heat antigen retrieval (pH=9) before standard IHF/IF staining
Format	50µl (approx. 40 tissue sections)

Citations

2025 Mahmoud et al., - Edaravone protects against cuprizone-induced demyelination in rats by modulating TNF-α/NF-ĸB/NLRP3 signaling and the kynurenine pathway, Eur J Pharmacol, Species : Rat ; Sample type : Brain ;
2024 Gliozzi M et al., - The dangerous “West Coast Swing” by hyperglycaemia and chronic stress in the mouse hippocampus: Role of kynurenine catabolism, Pharmacological Research, Species : Mouse ; Sample type : Serum ;
2023 Dongen et al., - Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis, bioRxiv, Species : Human ; Sample type : Plasma ;
2023 Kesarwani et al., - Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis, Nature Communications , Species : Human ; Sample type : Tumor tissues ;
2022 Sugisawa et al., - Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia, Cell reports, Species : Mouse ; Sample type : Brain ;

Frequently asked questions

IS002

Quinolinic acid Antibody – Mouse Monoclonal

This mouse monoclonal antibody to Quinolinic acid was validated for IF & IHC in human brain tissues. Recent publications relied on this antibody to stain for neurotoxin Quinolinic acid in mouse brain tissues and human atheroma plaques.

€449

Number of citations :

100 in stock

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Typical standard curve of Quinolinic acid ELISA

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IS002

Quinolinic acid Antibody – Mouse Monoclonal

Anti-Quinolinic acid mAb – Purified monoclonal antibody for research use only (liquid 50µL)

Specifications

Product name	Quinolinic acid mouse monoclonal antibody
Synonyms	Quinolinate antibody Pyridine-2,3-dicarboxylic acid antibody 2,3-pyridinedicarboxylic acid antibody 3,4-Pyridinedicarboxylic acid antibody Pyridine-3,4-dicarboxylic acid antibody
Immunogen	Conjugated quinolinic acid
Isotype	IgG1 k chain
Clone	Clone 4E11-G3
Specificity	When tested in competitive ELISA, the anti-Quinolinic acid antibody did not show any significant cross reactivity with Picolinic and Quinaldic acid conjugates
Volume	50 µL
Form	Liquid
Purity	Purified IgG

Instructions

Storage	Store at +4°C for short term (6 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles
Immunohistochemistry (IHC)	Dilute at 1:100-1:1000. Perform heat antigen retrieval (pH=9) before initiating IHC staining protocol on paraffin-embedded and frozen sections
Immunofluorescence (IF)	Dilute at 1:50-1:500 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate with fluorescent dyes conjugated secondary antibody
Comments	Optimal working dilutions must be determined by the end-user
Restrictions	For research use only