Quinolinic acid Monoclonal Antibody
Ref: IS002
Kynurenine pathwayTryptophan metabolismToxinsMonoclonal AntibodiesICCIFIHC

Quinolinic acid detection in human midbrain by immunohistofluorescence (IHF) Quinolinic acid detection in human midbrain by immunohistofluorescence (IHF) Quinolinic acid detection in human midbrain by immunohistochemistry (IHC) Anti- Quinolinic acid antibody affinity & specificity Quinolinic acid Quinolinic acid detection in human midbrain by immunohistofluorescence (IHF)
Immunofluorescence staining highlights nuclear exclusion of Quinolinic acid in human midbrain. Paraffin-embedded brain tissue section was subjected to pH=9 antigen retrieval followed by overnight incubation with primary anti-Quinolinic acid antibody (dilution 1/250). After incubation with Alexa-555 conjugated secondary Ab, epifluorescence microscopy (100X) was used to visualize the staining.
DatasheetMSDS
Confirmed to be highly specific and affine by competitive ELISA, the monoclonal anti- Quinolinic acid antibody 4E11-G3 was validated for immunofluorescence (IF) and immunohistochemistry (IHC) in human midbrain tissues.
Clonality | Monoclonal antibody (clone 4E11-G3) |
Host | Mouse |
Valided applications | IHC / IF |
Reactivity | Reacts with all species |
References | Not yet cited to our knowledge Submit content and get a 10% discount! |
Format | 50µL |
Size | 50µl |
---|
440.00€
91 in stock
Worldwide shipping
Product overview
Product name | Quinolinic acid antibody |
Synonyms | Pyridine-2,3-dicarboxylic acid antibody
2,3-pyridinedicarboxylic acid antibody 3,4-Pyridinedicarboxylic acid antibody Pyridine-3,4-dicarboxylic acid antibody |
Immunogen | Conjugated quinolinic acid |
Isotype | IgG1 k chain |
Clone | clone 4E11-G3 |
Specificity | When tested in competitive ELISA, the anti-Quinolinic acid antibody did not show any significant cross reactivity with Picolinic and Quinaldic acid conjugates |
Lot number | 140201 |
Expiration date | 2025-02-01 |
Storage
Form | Liquid |
Purity | Purified IgG |
Concentration | 0,5mg/ml |
Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
Material safety datasheet | Download MSDS |
Immunohistochemistry (IHC) | Dilute at 1:100-1:1000. Perform heat antigen retrieval (pH=9) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
Immunofluorescence (IF) | Dilute at 1:50-1:500 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate fluorescent dyes conjugated secondary antibody |
Comments | Optimal working dilutions must be determined by the end-user |
Restrictions | For research use only |
Product citation
- Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
Check the article
Authors : Sugisawa et al., Cell reports
2022-03