10/31/2019

Quinolinic Acid ELISA kit: NOW OUT!


The Quinolinic acid (QUIN or QA) ELISA kit is an easy-to-use assay tailored for the quantification of QA across large series of samples. Optimized for the analysis of serum samples, the QA ELISA features a lower limit of detection at (6ng/mL) and a minimal sample volume (25μL), thus allowing human ancillary studies.

  • 96-w plate format
  • Low volume samples
  • Sensitive, easy-to-implement
  • Cross-validated with LC/MS

Assay specifications

Format

96-well kit

Species reactivity

Any species

Samples

Serum

Sample volume

25μL

Sensitivity

< 6ng/mL

Assay range

25 - 2000 ng/mL

Assay time

Sample preparation: 2h ELISA: Overnight

 

Scientific background

Quinolinic acid (QA) is a metabolite produced along the Kynurenine Pathway, which converts the aminoacid Tryptophan to NAD+, a co-factor of many enzymatic reactions. It has been described to share several neurotoxic functions particularly through the activation of the N-Methyl-D-Aspartate receptor. Its production occurring in myeloid cells (macrophages, microglia, etc.) is mainly driven by inflammatory stress and is therefore suspected to play a key role in neuroinflammatory disorders such as Alzheimer and Parkinson diseases but also Multiple Sclerosis, Amyotrophic Lateral Sclerosis. Hence, while QA has been proposed as a biomarker in these indications, it might certainly warrant further investigation to serve as a surrogate in other “inflammation” related diseases such as cancer, metabolic disorders, etc.


 

 


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