Scientific Communications

Given the importance of the polyamine pathway in cancer progression and resistance to treatment, investigating it requires robust tools. To this aim, we developed and validated the first ELISA kits to quantify ornithine, N1-acetylspermidine, and N8-acetylspermidine in samples of different natures (plasma, cell culture supernatants) and different species (mouse, human).

Serotonin (5-HT) is one of the most potent monoamine neurotransmitters and peripheral signaling molecules. Physiologically, 5-HT has complex and diverse effects on the central and peripheral nervous systems, neuroendocrine regulation, and immunological responses. We recently developed and added to our catalog a novel antibody raised against 5-HT, compatible with formalin-fixed biological materials.

Given the importance of the Arginase pathway in pathophysiological processes, we have developed and validated a robust and easy-to-use immunoassay for the simultaneous detection and quantification of both L-Arginine and L-Ornithine in plasma / serum.

Among mechanisms associated with cancer immune evasion, the activation of the Kynurenine Pathway (KP) is known to play a key role and has thus been proposed as a therapeutic target to improve current immune checkpoint blockade-based immunotherapies.

L-Arginine is a key amino acid in the immune regulation and can be targeted as part of an anti-tumor response. We have thus developed and validated an ELISA kit for the detection and quatification of L-Arginine in biological samples.

New highlight in Annals of Oncology!
In this study, Peyraud at al. show that plasmatic level of L-Arginine (Arg) is associated with clinical outcome of patients treated with immune checkpoint blockers (ICB). Using an ELISA approach for Arg quantification (#IS-I-0400R) applied on two independent cohorts, authors demonstrated that low plasmatic level of Arg was associated with a worse clinical outcome.  

Among mechanisms associated with cancer immune evasion, the activation of the Kynurenine Pathway (KP) is known to play a key role and has thus been proposed as a therapeutic target to improve current immune checkpoint blockade-based immunotherapies.

Our Kynurenine/Tryptophan ELISA pack recently cited in Cancer Discovery in a publication written by Marta Galan-Diez et al. In this occasion, benefit from the spring sale on our Kynurenine / Tryptophan ELISA pack until April 30!

ImmuSmol products trusted by scientists and highlighted in recent publications!
Discover the recent studies where some of our top products have been used and have helped advance research.

Discover the scientific publications written in 2021 that cite Immusmol products! Antibodies, STAINperfect and ELISA kits were used and referenced in these recent articles that we have selected.
For more informations check out our product page!

We developed and validated a newSerine ELISA kit (#IS-I-1200) which allows for L-Ser quantitation in biological samples including plasma, sera as well as cell culture supernatants. The assay requires a low sample volume of 10μL and is characterized by a 2.4µM sensitivity.

Glutamine metabolism is an attractive therapeutic path in immuno-oncology. Glutamine level should rely mainly on Glutamine quantification, which can now be addressed by ELISA!