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Cinnabarinic acid detection by IHC in human breast tumorImmunohistochemical staining of human breast tumor tissue shows presence of Cinnabarinic acid in cells surrounding a necrotic area. Paraffin-embedded tumor tissue was subjected to pH=6 antigen retrieval before overnight incubation with primary anti-Cinnabarinic antibody (1/500 dilution). A polymer-conjugated secondary Ab was added and immunostaining was revealed using DAB.
Cinnabarinic acid detection by IHC in human caudate putamenIHC staining highlights the presence of Cinnabarinic acid in glial cells of the caudate-putamen region in human brain tissue. Paraffin-embedded tissue section was subjected to pH=6 antigen retrieval followed by overnight incubation with primary antibody (dilution 1/500). After incubation with polymer-conjugated secondary Ab, DAB was used to visualize the staining.
Specificity of anti-Cinnabarinic acid antibodyIHC staining highlights the presence of Cinnabarinic acid in glial cells of the caudate-putamen region in human brain tissue. Paraffin-embedded tissue section was subjected to pH=6 antigen retrieval followed by overnight incubation with primary antibody (dilution 1/500). After incubation with polymer-conjugated secondary Ab, DAB was used to visualize the staining.
Cinnabarinic acidCinnabarinic acid is a downstream metabolite of the kynurenine pathway wich is produced by condenstaion of two molecules of 3HAA. It was recently presented as an Aryl Hydrocarbon Receptor ligand driving IL-22 production. Also, Cinnabarinic acid was found to act as an orthosteric agonist of type-4 metabotropic glutamate (mGlu4) receptor 4, featuring anti-inflammatory activity.
Key features
| Clonality | Monoclonal antibody (clone 5C5-E10) |
| Host | Mouse |
| Reactivity | Reacts with all species |
| Tested samples | Human & rodent tissues (brain and tumor specimens) |
| Staining procedure | Perform heat antigen retrieval (pH=6) before standard IHF/IF staining |
| Format | 50µl (approx. 40 tissue sections) |
Frequently asked questions
Cinnabarinic acid Antibody – Mouse Monoclonal
The first and only validated anti-Cinnabarinic acid antibody available for research use. IHC validation of this mouse mAb in human brain and breast tumor tissues revealed the presence, in specific cells, of Cinnabarinic acid, a tryptophan metabolite known for its immunomodulatory role. A 2020 paper also used this anti-cinnabarinic antibody to stain mouse brain tissue sections (immunofluorescence).
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IS005
Cinnabarinic acid Antibody – Mouse Monoclonal
Anti-Cinnabarinic acid mAb – Purified monoclonal antibody for research use only (liquid 50µL)
Specifications
| Product name | Cinnabarinic acid antibody |
| Synonyms | 2-amino- 3-oxo- 3H-phenoxazine-1,9-dicarboxylic acid antibody |
| Immunogen | Conjugated Cinnabarinic acid |
| Isotype |
IgG1 k chain |
| Clone |
Clone 5C5-E10 |
| Specificity | When tested in competitive ELISA, the anti-Cinnabarinic acid antibody 5C5-E10 did not cross-react with its precursor, 3-OH-Anthranilic acid conjugates |
| Volume | 50 µL |
| Form | Liquid |
| Purity | Purified IgG |
Instructions
| Storage |
Store at +4°C for short term (6 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
| Immunohistochemistry (IHC) | Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
| Immunofluorescence (IF) |
Dilute at 1:100-1:1000 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate with fluorescent dyes conjugated secondary antibody |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
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