Kynurenic Acid ELISA kit
High Sensitivity – Serum

Ref: IS-I-0200R
Kynurenine pathwayTryptophan metabolismResearch ELISA kits (RUO)ELISA
DatasheetProtocolMSDS

Kynurenic acid (KYNA) is a downstream metabolite produced along the Kynurenine Pathway well-known to possess several neuromodulatory functions, as well as immuno-modulatory properties. Measurement of KYNA in biological samples has been presented as a possible biomarker in several diseases including neurological or psychiatric disorders.

The Kynurenic Acid ELISA kit is optimized for the quantitation of Kynurenic Acid (KYNA) within serum samples. This easy-to-use competitive assay is well-suited for both small and large series of samples. Working with a 50µL sample volume, this assay enables pre-clinical and clinical sample testings.

Sample type Serum
Capacity 96 tests
Sensitivity 2.8nM
Range 10 – 391nM
Assay time Sample derivatization 90 min, ELISA overnight
Reactivity Reacts with all species
References Cited in 5 papers
Size

1 x 96 wells

649.00

23 in stock

Quantity
Total

649.00

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Product overview

Product name Kynurenic Acid ELISA kit
Description Competitive ELISA kit for the quantitative measurement of Kynurenic Acid in serum samples. For research use only
Format 96-well plate
Samples Serum
Minimal sample volume 50µL
Reactivity Reacts with all species
Standard range 1.40 – 74ng/mL
Sensitivity

0.53ng/mL

Specificity No significant cross-reactivity was observed with Kynurenic Acid analogs such as Quinolinic Acid, Xanthurenic acid, Kynurenine, Picolinic acid, 3-Hydroxy-Anthranilic Acid
Assay time Sample derivatization 90 min and ELISA overnight
Storage Store at 2-8°C for up to 6 months
Datasheets Instructions for useMaterial Safety Datasheet

Sample collection & storage Serum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands

Store samples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months)

Sample preparation Sample derivatization (90 min)
ELISA Kynurenic acid antiserum overnight incubation, revelation and read steps (1h)
Detailed protocol Download instructions for use

Product citations

  • Advances in kynurenine analysis
    Check the article
    Authors : Mrstna et al., Clinica Chimica Acta
    2023-07
  • Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
    Check the article
    Authors : Dongen et al., bioRxiv
    2023-07
  • Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions
    Check the article
    Authors : Cremone et al., Biomedicines
    2023-04
  • Alzheimer’s-like signaling in brains of COVID-19 patients
    Check the article
    Authors : Reiken et al., Alzheimer's & Dementia
    2022-02
  • Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives
    Check the article
    Authors : Sadok et al., Sensors
    2021-10

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