Antibodies & immunoassays for small molecules Kynurenic Acid ELISA kit
High Sensitivity – Serum
Ref: IS-I-0200R
Kynurenine pathwayTryptophan metabolismResearch ELISA kits (RUO)ELISA
+Kynurenic acid ELISA kit
DatasheetProtocolMSDS
Kynurenic acid (KYNA) is a downstream metabolite produced along the Kynurenine Pathway well-known to possess several neuromodulatory functions, as well as immuno-modulatory properties. Measurement of KYNA in biological samples has been presented as a possible biomarker in several diseases including neurological or psychiatric disorders.
The Kynurenic Acid ELISA kit is optimized for the quantitation of Kynurenic Acid (KYNA) within serum samples. This easy-to-use competitive assay is well-suited for both small and large series of samples. Working with a 50µL sample volume, this assay enables pre-clinical and clinical sample testings.
| Sample type | Serum |
| Capacity | 96 tests |
| Sensitivity | 2.8nM |
| Range | 10 – 391nM |
| Assay time | Sample derivatization 90 min, ELISA overnight |
| Reactivity | Reacts with all species |
| References | Cited in 10 papers |
They published with this product see papers
Product overview
| Product name | Kynurenic Acid ELISA kit |
| Description | Competitive ELISA kit for the quantitative measurement of Kynurenic Acid in serum samples. For research use only |
| Format | 96-well plate |
| Samples | Serum |
| Minimal sample volume | 50µL |
| Reactivity | Reacts with all species |
| Standard range | 1.40 – 74ng/mL |
| Sensitivity |
0.53ng/mL |
| Specificity | No significant cross-reactivity was observed with Kynurenic Acid analogs such as Quinolinic Acid, Xanthurenic acid, Kynurenine, Picolinic acid, 3-Hydroxy-Anthranilic Acid |
| Assay time | Sample derivatization 90 min and ELISA overnight |
| Storage | Store at 2-8°C for up to 6 months |
| Datasheets | Instructions for use, Material Safety Datasheet |
| Sample collection & storage | Serum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands
Store samples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months) |
| Sample preparation | Sample derivatization (90 min) |
| ELISA | Kynurenic acid antiserum overnight incubation, revelation and read steps (1h) |
| Detailed protocol | Download instructions for use |
Product citations
- Edaravone protects against cuprizone-induced demyelination in rats by modulating TNF-α/NF-ĸB/NLRP3 signaling and the kynurenine pathway
Check article
Authors : Mahmoud et al., Eur J Pharmacol
2025-04 - Acute and chronic effects of physical exercise on atherosclerosis, kynurenine pathway, endothelial function and inflammation in patients with coronary artery disease: a clinical trial protocol
Check article
Authors : Andrade Paz et al., BMJ Open Sport Exerc Med
2025-02 - Continuous theta burst stimulation for bipolar depression: A multicenter, double-blind randomized controlled study exploring treatment efficacy and predictive potential of kynurenine metabolites
Check the article
Authors : Dellink et al., Journal of Affective Disorders
2024-09 - The importance of oxidative stress and the kynurenine pathway of tryptophan metabolsm in the onset and development of multiple sclerosis in the population of Serbia
Check article
Authors : Marija Vasic, Thesis
2024-02 - Advances in kynurenine analysis
Check the article
Authors : Mrstna et al., Clinica Chimica Acta
2023-07 - Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
Check the article
Authors : Dongen et al., bioRxiv
2023-07 - Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials
Check article
Authors : Girithar et al., British Journal of Cancer
2023-04 - Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions
Check the article
Authors : Cremone et al., Biomedicines
2023-04 - Alzheimer’s-like signaling in brains of COVID-19 patients
Check the article
Authors : Reiken et al., Alzheimer's & Dementia
2022-02 - Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives
Check the article
Authors : Sadok et al., Sensors
2021-10
