L-Kynurenine Antibody – Mouse Monoclonal

Ref: IS003
Monoclonal AntibodiesICCIFIHCKynurenine pathwayTryptophan metabolism
DatasheetMSDS

Our anti-L-Kynurenine antibody IS1003 enabled to illustrate, for the first time, the presence of L-kynurenine in human brain and tumor samples by IHC and IF. This mouse monocloncal antibody can be used in combination with other primary antibodies to kynurenine metabolites (rabbit polycloncals avaible).

Clonality Monoclonal antibody (clone 3D4-F2)
Host Mouse
Validated applications IHC / IF
Reactivity Reacts with all species
Format 50µL
References Cited in 9 papers 
Size

50µl

440.00

52 in stock

Quantity
Total

440.00

Worldwide shipping

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Product overview

Product name L-Kynurenine antibody
Synonyms (S)-Kynurenine antibody

L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid antibody

Kynurenin antibody

3-Anthraniloyl-L-alanine antibody,

Immunogen Conjugated L-Kynurenine
Isotype IgG1 k chain
Clone clone 3D4-F2
Specificity When tested in competitive ELISA, the anti-L-Kynurenine antibody did not show any significant cross reactivity with L-Tryptophan, 3-hydroxy-DL-Kynurenine, Kynurenic acid, Anthranilic acid or 3-hydroxyAnthranilic acid conjugates

Storage

Form Liquid
Purity Purified IgG
Concentration 0,5mg/ml
Storage
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles
Material safety datasheet Download MSDS

Immunohistochemistry (IHC) Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating IHC staining protocol on paraffin-embedded and frozen sections
Immunofluorescence (IF) Dilute at 1:100-1:1000 on paraffin-embedded and frozen sections. Before staining, perform heat antigen retrieval
Comments Optimal working dilutions must be determined by the end-user
Restrictions For research use only

Product citations

  • Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
    Check the article
    Authors : Dongen et al., bioRxiv
    2023-07
  • Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication
    Check the article
    Authors : Gargaro et al., Immunity
    2022-06
  • Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma
    Check the article
    Authors : Sumitomo et al., Cancer Science
    2021-01
  • Kynurenine signaling through the aryl hydrocarbon receptor maintains the undifferentiated state of human embryonic stem cells
    Check the article
    Authors : Yamamoto et al., Science signaling
    2019-06
  • Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
    Check the article
    Authors : Takenaka et al., Nature neuroscience
    2019-04
  • Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice
    Check the article
    Authors : Forteza et al., Frontiers in immunology
    2018-05
  • Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
    Check the article
    Authors : Maliniemi et al., Oncoimmunology
    2017-02
  • Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers
    Check the article
    Authors : Puccetti et al., PloS one
    2015-04

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