L-Kynurenine Monoclonal Antibody

Ref: IS003
Kynurenine pathwayMonoclonal AntibodiesICCIFIHC
DatasheetMSDS

Monoclonal anti-L-Kynurenine antibody 3D4-F2 enabled to illustrate, for the first time, the presence of L-kynurenine in human brain and tumor samples by IHC and IF. Recently, our anti-kynurenine antibody was used to stratify cancer patients for kynurenine pathway activity (open-access PLOS ONE article).

Clonality Monoclonal antibody (clone 3D4-F2)
Host Mouse
Validated applications IHC / IF
Reactivity Reacts with all species
References 5 citations
Format 50µL
Size

50µl

440.00

91 in stock

Quantity
Total

440.00

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Product overview

Product name L-Kynurenine antibody
Synonyms (S)-Kynurenine antibody

L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid antibody

Kynurenin antibody

3-Anthraniloyl-L-alanine antibody,

Immunogen Conjugated L-Kynurenine
Isotype IgG1 k chain
Clone clone 3D4-F2
Specificity When tested in competitive ELISA, the anti-L-Kynurenine antibody did not show any significant cross reactivity with L-Tryptophan, 3-hydroxy-DL-Kynurenine, Kynurenic acid, Anthranilic acid or 3-hydroxyAnthranilic acid conjugates

Storage

Form Liquid
Purity Purified IgG
Concentration 0,5mg/ml
Storage
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles
Material safety datasheet Download MSDS

Immunohistochemistry (IHC) Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating IHC staining protocol on paraffin-embedded and frozen sections
Immunofluorescence (IF) Dilute at 1:100-1:1000 on paraffin-embedded and frozen sections. Before staining, perform heat antigen retrieval
Comments Optimal working dilutions must be determined by the end-user
Restrictions For research use only

Product citation

  • Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication
    Check the article
    Authors : Gargaro et al., Immunity
    2022-06
  • Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication
    Check the article
    Authors : Gargaro et al., Immunity
    2022-06
  • Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma
    Check the article
    Authors : Sumitomo et al., Cancer Science
    2021-01
  • Kynurenine signaling through the aryl hydrocarbon receptor maintains the undifferentiated state of human embryonic stem cells
    Check the article
    Authors : Yamamoto et al., Science signaling
    2019-06
  • Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
    Check the article
    Authors : Takenaka et al., Nature neuroscience
    2019-04
  • Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice
    Check the article
    Authors : Forteza et al., Frontiers in immunology
    2018-05
  • Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
    Check the article
    Authors : Maliniemi et al., Oncoimmunology
    2017-02
  • Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers
    Check the article
    Authors : Puccetti et al., PloS one
    2015-04

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