L-Kynurenine Antibody – Mouse Monoclonal
Ref: IS003
Monoclonal AntibodiesICCIFIHCKynurenine pathwayTryptophan metabolism
DatasheetMSDS
Our anti-L-Kynurenine antibody IS1003 enabled to illustrate, for the first time, the presence of L-kynurenine in human brain and tumor samples by IHC and IF. This mouse monoclonal antibody can be used in combination with other primary antibodies to kynurenine metabolites (rabbit polyclonals available).
Clonality | Monoclonal antibody (clone 3D4-F2) |
Host | Mouse |
Validated applications | IHC / IF |
Reactivity | Reacts with all species |
Format | 50µL |
References | Cited in 10 papers |
Size | 50µl |
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440.00€
49 in stock
Worldwide shipping
They published with this product see papers
Product overview
Product name | L-Kynurenine antibody |
Synonyms | (S)-Kynurenine antibody
L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid antibody Kynurenin antibody 3-Anthraniloyl-L-alanine antibody, |
Immunogen | Conjugated L-Kynurenine |
Isotype | IgG1 k chain |
Clone | clone 3D4-F2 |
Specificity | When tested in competitive ELISA, the anti-L-Kynurenine antibody did not show any significant cross reactivity with L-Tryptophan, 3-hydroxy-DL-Kynurenine, Kynurenic acid, Anthranilic acid or 3-hydroxyAnthranilic acid conjugates |
Storage
Form | Liquid |
Purity | Purified IgG |
Concentration | 0,5mg/ml |
Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
Material safety datasheet | Download MSDS |
Immunohistochemistry (IHC) | Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
Immunofluorescence (IF) | Dilute at 1:100-1:1000 on paraffin-embedded and frozen sections. Before staining, perform heat antigen retrieval |
Comments | Optimal working dilutions must be determined by the end-user |
Restrictions | For research use only |
Product citations
- The Aryl Hydrocarbon Receptor Controls IFNγ-Induced Immune Checkpoints PD-L1 and IDO via the JAK/STAT Pathway in Lung Adenocarcinoma
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Authors : Snyder et al., BioRxiv
2024-08 - The dangerous “West Coast Swing” by hyperglycaemia and chronic stress in the mouse hippocampus: Role of kynurenine catabolism
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Authors : Gliozzi M et al., Pharmacological Research
2024-01 - Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
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Authors : Dongen et al., bioRxiv
2023-07 - Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication
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Authors : Gargaro et al., Immunity
2022-06 - Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma
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Authors : Sumitomo et al., Cancer Science
2021-01 - Kynurenine signaling through the aryl hydrocarbon receptor maintains the undifferentiated state of human embryonic stem cells
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Authors : Yamamoto et al., Science signaling
2019-06 - Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
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Authors : Takenaka et al., Nature neuroscience
2019-04 - Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice
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Authors : Forteza et al., Frontiers in immunology
2018-05 - Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
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Authors : Maliniemi et al., Oncoimmunology
2017-02 - Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers
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Authors : Puccetti et al., PloS one
2015-04