Kynurenic Acid/Quinolinic Acid ELISA pack – High Sensitivity

Ref: ISE-0102R
Kynurenine pathwayTryptophan metabolismResearch ELISA kits (RUO)ELISA
DatasheetMSDS Kynurenic AcidProtocol Kynurenic AcidMSDS Quinolinic AcidProtocol Quinolinic Acid

Through the degradation of L-Tryptophan, the Kynurenine pathway (KP) generates a series of catabolites collectively known as Kynurenines, which can exert immunomodulatory and/or neuroactive properties. Known to respectively harbor neuroprotective and neurotoxic functions, Kynurenic (KYNA) and Quinolinic (QA) acids are found to be dysregulated in several neuroinflammatory disorders including Parkinson and Alzheimer disease but also Amyotrophic Lateral Sclerosis and Multiple Sclerosis.

Indended for research use only, the two kits included in the pack are ready to use, optimized for the quantitation of Kynurenic Acid (KYNA) and Quinolinic Acid (QA) within serum and plasma samples. These easy-to-use competitive assays are well-suited for both small and large series of samples. Working with a 25-50µL sample volume, these assays enable pre-clinical and clinical sample testings.

 

Sample typeSerum, Plasma
Kit capacity2 x 96 tests
SensitivityLoD KYNA: 0.53ng/ml

LoD QA: 6ng/ml

RangeKYNA: 1.40 – 74ng/ml

QA: 25 – 200ng/ml

ReactivityReacts with all species
References5 papers with KYNA kit, 6 papers with QA kit
Size

2 x 96 wells

1,170.21

95 in stock

Quantity
Total

1,170.21

Worldwide shipping

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Product overview

Product nameKynurenic Acid/Quinolinic Acid ELISA pack
DescriptionTwo enzyme immunoassays (ELISA) allowing the quantitative determination of Kynurenic acid and Quinolinic acid in serum samples. For research use only
LabelsRUO
Format2 x 96-well plate
SamplesSerum, Plasma
Minimum sample volume25-50µL
ReactivityReacts with all species
Standard rangeKYNA: 1.40 – 74ng/ml

QA: 25 – 2000ng/ml

Sensitivity

LoD KYNA: 0.53ng/ml

LoD QA: 6ng/ml

SpecificityNo significant cross-reactivity was observed analogs for each kit. See product pages for Kynurenic acid ELISA and Quinolinic acid ELISA
StorageStore at 2-8°C for to 6 months
DatasheetsInstructions for use – KYNA kitInstructions for use – QA kit

Safety datasheet – KYNA kit, Safety datasheet QA kit

Sample collection & storageSerum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands. Store samples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months)
Sample preparationKYNA: Sample derivatization (90 min)

QA: Sample acylation (120 min)

ELISAAntisera overnight incubation, revelation and read steps (1h)
Detailed protocolInstructions for use – KYNA kitInstructions for use – QA kit

Product citations

  • Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
    Check the article
    Authors : Dongen et al., bioRxiv
    2023-07
  • Advances in kynurenine analysis
    Check the article
    Authors : Mrstna et al., Clinica Chimica Acta
    2023-07
  • Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions
    Check the article
    Authors : Cremone et al., Biomedicines
    2023-04
  • Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
    Check the article
    Authors : Sugisawa et al., Cell reports
    2022-03
  • Alzheimer’s-like signaling in brains of COVID-19 patients
    Check the article
    Authors : Reiken et al., Alzheimer's & Dementia
    2022-02
  • Apathy is not associated with a panel of biomarkers in older adults with HIV disease
    Check the article
    Authors : Wood et al., Journal of psychosomatic research
    2021-11
  • Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives
    Check the article
    Authors : Sadok et al., Sensors
    2021-10
  • Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial
    Check the article
    Authors : Chaiyasut et al, Foods
    2021-07

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