Kynureninic Acid/Quinolinic Acid ELISA pack

Ref: ISE-0102R
Kynurenine pathwayTryptophan metabolismResearch ELISA kits (RUO)ELISA
DatasheetMSDS Kynurenic AcidProtocol Kynurenic AcidMSDS Quinolinic AcidProtocol Quinolinic Acid

Through the degradation of L-Tryptophan, the Kynurenine pathway (KP) generates a series of catabolites collectively known as Kynurenines, which can exert immunomodulatory and/or neuroactive properties. Known to respectively harbor neuroprotective and neurotoxic functions, Kynurenic (KYNA) and Quinolinic (QA) acids are found to be dysregulated in several neuroinflammatory disorders including Parkinson and Alzheimer disease but also Amyotrophic Lateral Sclerosis and Multiple Sclerosis.

Indended for research use only, the two kits included in the pack are ready to use, optimized for the quantitation of Kynurenic Acid (KYNA) and Quinolinic Acid (QA) within serum and plasma samples. These easy-to-use competitive assays are well-suited for both small and large series of samples. Working with a 25-50µL sample volume, these assays enable pre-clinical and clinical sample testings.

 

Sample type Serum, Plasma
Kit capacity 2 x 96 tests
Sensitivity LoD KYNA: 0.53ng/ml

LoD QA: 6ng/ml

Range KYNA: 1.40 – 74ng/ml

QA: 25 – 200ng/ml

Reactivity Reacts with all species
Size

2 x 96 wells

990.00

100 in stock

Quantity
Total

990.00

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Product overview

Product name Kynurenic Acid/Quinolinic Acid ELISA pack
Description Two enzyme immunoassays (ELISA) allowing the quantitative determination of Kynurenic acid and Quinolinic acid in serum samples. For research use only
Labels RUO
Format 2 x 96-well plate
Samples Serum, Plasma
Minimum sample volume 25-50µL
Reactivity Reacts with all species
Standard range KYNA: 1.40 – 74ng/ml

QA: 25 – 2000ng/ml

Sensitivity

LoD KYNA: 0.53ng/ml

LoD QA: 6ng/ml

Specificity No significant cross-reactivity was observed analogs for each kit. See product pages for Kynurenic acid ELISA and Quinolinic acid ELISA
Storage Store at 2-8°C for to 6 months
Datasheets Instructions for use – KYNA kitInstructions for use – QA kit

Safety datasheet – KYNA kit, Safety datasheet QA kit

Sample collection & storage Serum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands. Store samples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months)
Sample preparation KYNA: Sample derivatization (90 min)

QA: Sample acylation (120 min)

ELISA Antisera overnight incubation, revelation and read steps (1h)
Detailed protocol Instructions for use – KYNA kitInstructions for use – QA kit

Selected articles on Kynurenic acid

 

Selected articles on Quinolinic acid

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