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Novel therapeutic options in immuno-oncology consist in manipulating – directly or indirectly – metabolic pathways such as the one of IDO to relieve the immunosupressive functions of M2 macrophages. As to investigate innovative direct or indirect modulators of IDO activity, Kynurenine and Tryptophan represent valuable biomarkers to be measured and can easily be adressed through ELISA kits which thus offer screening capacities.

Arginine (ARG) is a basic non-essential amino acid well known to participate in physiological functions such as i) vascular tone homeostasis as contributing to the production of nitric oxide (NO) and ii) immune response control, through NO synthase (NOS) and Arginase enzymes, respectively. Our new validated IS-I-0400 ELISA kit allows for the determination of ARG in serum and plasma samples of a volume as low as 20μL and with a sensitivity of 2.1µM.

Through the degradation of L-Tryptophan, the Kynurenine pathway (KP) generates a series of catabolites collectively known as Kynurenines, which can exert immunomodulatory and/or neuroactive properties. Known to respectively harbor neuroprotective and neurotoxic functions, Kynurenic (KYNA) and Quinolinic (QA) acids are found to be dysregulated in several neuroinflammatory disorders including Parkinson and Alzheimer disease but also Amyotrophic Lateral Sclerosis and Multiple Sclerosis. We developed novel ELISA detection kits to monitor the imbalance between KYNA and QA levels in neurological diseases and evaluate the ability of novel KMO inhibitors to restore equilibrium within the KP and mitigate neurodegeneration.

HomoArginine (hArg) is a basic non-essential amino acid that exerts beneficial effects on vascular homeostasis, more likely through the increase of nitric oxide (NO) that can be explained through two mechanisms since hArg i) serves as a precursor of NO and ii) favors the elevation of L-Arg – main substrate of NO synthase – by inhibiting the enzyme Arginase. Our IS-I-0500 ELISA kit allows for the determination of hArg in serum and plasma samples in a minimal sample volume of 20μL and with a sensitivity of 125nM.

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Kynurenine and tryptophan as surrogate immune suppression tumor biomarkers

Summer sale 2019 ! 20% off on ELISA kits and 30% off on antibodies