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TH expression does not necessarily indicate that neurons are metabolically active and produce dopamine. Therefore, several groups interested in organoid-based modeling of Parkinson’s disease have combined standard markers of dopaminergic neurons, such as TH and GIRK2, with direct staining of dopamine using anti-hapten antibodies, as well as ELISA kits for quantifying dopamine release in supernatant.

Catch up on our top highlights from this year!

Hear about our new ELISA kits and antibodies to assess the polyamine pathway and reveal serotonin, as well as the peer-reviewed papers that referenced our products!

Benefit from our current special offer on a range of specific and highly sensitive ELISA kits to obtain valuable quantitative data on monoamine levels in various fluids, including blood and urine.

Serotonin (5HT) is one of the most potent monoamine neurotransmitters and peripheral signaling molecules. Therefore, tools allowing for the evaluation of serotonergic systems are valuable to approach the complex 5HT activities in physiological and pathological situations, but also to investigate mechanisms of action of novel disease-targeting therapies. For this purpose, we have set up and validated a series of experimental immunoassays specifically raised against 5HT.

Given the importance of the polyamine pathway in cancer progression and resistance to treatment, investigating it requires robust tools. To this aim, we developed and validated the first ELISA kits to quantify ornithine, N1-acetylspermidine, and N8-acetylspermidine in samples of different natures (plasma, cell culture supernatants) and different species (mouse, human).

Benefit from our current special offer on a range of specific and highly sensitive ELISA kits to obtain valuable quantitative data on monoamine levels in various fluids, including blood and urine.

Serotonin (5-HT) is one of the most potent monoamine neurotransmitters and peripheral signaling molecules. Physiologically, 5-HT has complex and diverse effects on the central and peripheral nervous systems, neuroendocrine regulation, and immunological responses. We recently developed and added to our catalog a novel antibody raised against 5-HT, compatible with formalin-fixed biological materials.

Given the importance of the Arginase pathway in pathophysiological processes, we have developed and validated a robust and easy-to-use immunoassay for the simultaneous detection and quantification of both L-Arginine and L-Ornithine in plasma / serum.

Among mechanisms associated with cancer immune evasion, the activation of the Kynurenine Pathway (KP) is known to play a key role and has thus been proposed as a therapeutic target to improve current immune checkpoint blockade-based immunotherapies.

2023 is near, but there’s still time to check out our best highlights of the second half of 2022! Stay connected, great things are coming next year!

L-Arginine is a key amino acid in the immune regulation and can be targeted as part of an anti-tumor response. We have thus developed and validated an ELISA kit for the detection and quatification of L-Arginine in biological samples.

Don’t miss this offer! Take a tour of our product webpage to select your favorites and benefit from this season’s offer to try them!