Kynurenine / Tryptophan ratio ELISA pack I High Sensitivity

Ref: ISE-2227
Kynurenine pathwayTryptophan metabolismDiagnostic ELISA kits (IVD)Research ELISA kits (RUO)ELISA
DatasheetMSDS TryptophanMSDS Kynurenine

The Kynurenine/Tryptophan ratio ELISA pack enables quantitative measurements of tryptophan catabolism along the kynurenine pathway in a large number of samples. The two kits included in the pack are ready to use. Highly sensitive, with a minimum sample volume of 20µl, they permit the performance of longitudinal studies in mice.

Sample typePlasma, Serum, Cell culture supernatant, (Urine)
Kit capacity2 x 96 tests
SensitivityLoD KYN: < 47.5ng/ml
LoD TRP: < 1.2µg/ml
RangeKYN: 0/100 – 10000ng/ml
TRP: 2.5 – 250µg/ml
ReactivityReacts with all species
References Cited in >30 papers
Size

2 x 96 wells

Regulatory status

In Vitro Diagnostics (EU), Research Use Only

941.00

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941.00

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Product overview

Product nameKynurenine/Tryptophan ratio ELISA pack – composed of 1 x BA-E2200 kit and 1 x BA-E-2700 kit
DescriptionTwo enzyme immunoassays (ELISA) allowing the quantitative determination of L-Kynurenine to L-Tryptophan ratio in urine, plasma and serum samples
LabelsCE, IVD
Format2 x 96-well plate
SamplesPlasma, serum, cell culture supernatant, (Urine)
Minimum sample volume20µL
ReactivityReacts with all species
Standard rangeKYN: 0/100 – 10000ng/ml
TRP: 2.5 – 250µg/ml
Sensitivity

LoD KYN: < 47.5ng/ml
LoD TRP: < 1.2µg/ml

SpecificityNo significant cross-reactivity was observed with L-Tryptophan and L-Kynurenine analogs. See product pages for L-Kynurenine ELISA  and L-Tryptophan ELISA
StorageStore at 2-8°C for to 6 months
DatasheetsIVD: Instructions for use – TRP kit, Instructions for use -KYN kit

RUO: Instructions for use – TRP kit, Instructions for use -KYN kit

 

Sample collection & storagePlasma/Serum: EDTA-, Heparin- or Citrate- samples stored at 2-8°C for up to 48h or -20°C for longer period (up to 6 months)
Sample preparationKYN: Sample acylation (90 min)
TRP: Sample precipitation (15 min) and derivatization (2h)
ELISAAntisera overnight incubation, revelation and read steps (1h)
Detailed protocolIVD: Instructions for use – TRP kit, Instructions for use – KYN kit

RUO: Instructions for use TRP kit, Instructions for use – KYN kit

Product citation

  • Sphingomyelin-derived nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance metastatic and post-surgical melanoma immunotherapy
    Check the article
    Authors : Wang et al., Nature Communications
    2023-11
  • An open label randomized controlled trial of atorvastatin versus aspirin in elite controllers and antiretroviral-treated people with HIV
    Check the article
    Authors : Mystakeli et al., AIDS
    2023-10
  • Hypomethylation-induced regulatory programs in T cells unveiled by transcriptomic analyses
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    Authors : Lysandrou et al., Frontiers in Immunology
    2023-09
  • Pathogenetic associations of anti-ribosomal P protein antibody titres and their subclasses in patients with systemic lupus erythematosus
    Check the article 
    Authors : Kaneko et al., Rheumatology
    2023-08
  • Effects of Supplementation with the Standardized Extract of Saffron (affron®) on the Kynurenine Pathway and Melatonin Synthesis in Rats
    Check the article
    Authors : Munoz et al., Antioxydants
    2023-07
  • Advances in kynurenine analysis
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    Authors : Mrstna et al., Clinica Chimica Acta
    2023-07
  • Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials
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    Authors : Girithar et al., British Journal of Cancer
    2023-04
  • Tryptophan degradation enzymes expression in the placenta and the Kynurenine/Tryptophan ratio in maternal plasma after elective cesarean section
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    Authors : Silvano et al., Journal of Reproductive Immunology
    2023-02
  • Citrulline and kynurenine to tryptophan ratio: potential EED (environmental enteric dysfunction) biomarkers in acute watery diarrhea among children in Bangladesh
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    Authors : Das et al., Scientific Reports
    2023-01
  • Tryptophan degradation enzymes and Angiotensin (1−7) expression in human placenta
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    Authors : Silvano et al., Journal of Reproductive Immunology
    2022-09
  • Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
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    Authors : Sugisawa et al., Cell reports
    2022-03
  • Tryptophan Metabolism Is Associated with BMI and Adipose Tissue Mass and Linked to Metabolic Disease in Pediatric Obesity
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    Authors : Lischka et al, Nutrients
    2022-01
  • The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation
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    Authors : Eleftheriadis et al., Biomolecules
    2021-10
  • Plasma Kynurenine-to- Tryptophan Ratio, a Highly Sensitive Blood-Based Diagnostic Tool for Tuberculosis in Pregnant Women Living With Human Immunodeficiency Virus (HIV)
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    Authors : Adu-Gyamfi et al., Clinical infectious Diseases
    2021-10
  • The effects of high-monosaccharide diets on development and biochemical composition of white-eyed mutant strain of house cricket (Acheta domesticus)
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    Authors : Francikowski et al., Scientific reports
    2021-10
  • Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
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    Authors : Wang et al., Frontiers in microbiology
    2021-06
  • Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza
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    Authors : Jung Cho et al., European Respiratory Journal
    2021-05
  • Pali_peridone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways
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    Authors : MacDowell et al., Frontiers in pharmacology
    2021-05
  • Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells
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    Authors : Eleftheriadis et al., Molecular Medicine Reports
    2021-04
  • Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
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    Authors : Bekki et al., PloS one
    2020-10
  • Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans
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    Authors : Baumgartner et al., Journal of internal medicine
    2020-08
  • Diagnostic accuracy of plasma kynurenine/tryptophan ratio, measured by enzyme-linked immunosorbent assay, for pulmonary tuberculosis
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    Authors : Adu-Gyamfi et al., International journal of infectious diseases
    2020-08
  • Effect of repetitive transcranial magnetic stimulation on the kynurenine pathway in stroke patients
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    Authors : Masachika et al., Clinical neuroscience
    2020-06
  • Prognostic value of indoleamine 2,3 dioxygenase in patients with higher-risk myelodysplastic syndromes treated with azacytidine
    Check the article
    Authors : Müller-Thomas et al., British journal of haematology
    2020-04
  • IDO Targeting in Sarcoma: Biological and Clinical Implications
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    Authors : Nafia et al., Frontiers in immunology
    2020-03
  • Blood Predictive Biomarkers for Patients With Non-small-cell Lung Cancer Associated With Clinical Response to Nivo_lumab
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    Authors : Agullo-Ortuno et al., Clinical lung cancer
    2019-08
  • Traumatic injury leads to inflammation and altered tryptophan metabolism in the juvenile rabbit brain
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    Authors : Zhang et al., Journal of Neurotrauma
    2018-09
  • Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice
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    Authors : Walker et al., Molecular Psychiatry
    2018-07
  • Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats
    Check the article
    Authors : Martin-Hernandez et al., Molecular Neurobiology
    2018-05
  • Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas: A Phase 2 Clinical Trial
    Check the article
    Authors : Toulmonde et al., JAMA oncology
    2018-01
  • Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections
    Check the article
    Authors : Ziklo et al., Frontiers in cellular and infection microbiology
    2018-01

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