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Kynurenine / Tryptophan ratio ELISA pack I High Sensitivity
Ref: ISE-2227Kynurenine pathwayTryptophan metabolismDiagnostic ELISA kits (IVD)Research ELISA kits (RUO)ELISA
+Kynurenine / Tryptophan ratio ELISA pack
DatasheetMSDS TryptophanMSDS Kynurenine
The Kynurenine/Tryptophan ratio ELISA pack enables quantitative measurements of tryptophan catabolism along the kynurenine pathway in a large number of samples. The two kits included in the pack are ready to use. Highly sensitive, with a minimum sample volume of 20µl, they permit the performance of longitudinal studies in mice.
| Sample type | Plasma, Serum, Cell culture supernatant, (Urine) |
| Kit capacity | 2 x 96 tests |
| Sensitivity | LoD KYN: < 47.5ng/ml LoD TRP: < 1.2µg/ml |
| Range | KYN: 0/100 – 10000ng/ml TRP: 2.5 – 250µg/ml |
| Reactivity | Reacts with all species |
| References | Cited in >30 papers |
Product overview
| Product name | Kynurenine/Tryptophan ratio ELISA pack – composed of 1 x BA-E2200 kit and 1 x BA-E-2700 kit |
| Description | Two enzyme immunoassays (ELISA) allowing the quantitative determination of L-Kynurenine to L-Tryptophan ratio in urine, plasma and serum samples |
| Labels | CE, IVD |
| Format | 2 x 96-well plate |
| Samples | Plasma, serum, cell culture supernatant, (Urine) |
| Minimum sample volume | 20µL |
| Reactivity | Reacts with all species |
| Standard range | KYN: 0/100 – 10000ng/ml TRP: 2.5 – 250µg/ml |
| Sensitivity | LoD KYN: < 47.5ng/ml |
| Specificity | No significant cross-reactivity was observed with L-Tryptophan and L-Kynurenine analogs. See product pages for L-Kynurenine ELISA and L-Tryptophan ELISA |
| Storage | Store at 2-8°C for to 6 months |
| Datasheets | IVD: Instructions for use – TRP kit, Instructions for use -KYN kit RUO: Instructions for use – TRP kit, Instructions for use -KYN kit |
| Sample collection & storage | Plasma/Serum: EDTA-, Heparin- or Citrate- samples stored at 2-8°C for up to 48h or -20°C for longer period (up to 6 months) |
| Sample preparation | KYN: Sample acylation (90 min) TRP: Sample precipitation (15 min) and derivatization (2h) |
| ELISA | Antisera overnight incubation, revelation and read steps (1h) |
| Detailed protocol | IVD: Instructions for use – TRP kit, Instructions for use – KYN kit RUO: Instructions for use TRP kit, Instructions for use – KYN kit |
Product citation
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2023-07 - Advances in kynurenine analysis
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Authors : Mrstna et al., Clinica Chimica Acta
2023-07 - Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials
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Authors : Girithar et al., British Journal of Cancer
2023-04 - Tryptophan degradation enzymes expression in the placenta and the Kynurenine/Tryptophan ratio in maternal plasma after elective cesarean section
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Authors : Silvano et al., Journal of Reproductive Immunology
2023-02 - Citrulline and kynurenine to tryptophan ratio: potential EED (environmental enteric dysfunction) biomarkers in acute watery diarrhea among children in Bangladesh
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Authors : Das et al., Scientific Reports
2023-01 - Tryptophan degradation enzymes and Angiotensin (1−7) expression in human placenta
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Authors : Silvano et al., Journal of Reproductive Immunology
2022-09 - Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
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Authors : Sugisawa et al., Cell reports
2022-03 - Tryptophan Metabolism Is Associated with BMI and Adipose Tissue Mass and Linked to Metabolic Disease in Pediatric Obesity
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Authors : Lischka et al, Nutrients
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Authors : Eleftheriadis et al., Biomolecules
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Authors : Adu-Gyamfi et al., Clinical infectious Diseases
2021-10 - The effects of high-monosaccharide diets on development and biochemical composition of white-eyed mutant strain of house cricket (Acheta domesticus)
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Authors : Francikowski et al., Scientific reports
2021-10 - Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
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Authors : Wang et al., Frontiers in microbiology
2021-06 - Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza
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Authors : Jung Cho et al., European Respiratory Journal
2021-05 - Pali_peridone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways
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2021-05 - Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells
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2021-04 - Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
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2020-10 - Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans
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Authors : Baumgartner et al., Journal of internal medicine
2020-08 - Diagnostic accuracy of plasma kynurenine/tryptophan ratio, measured by enzyme-linked immunosorbent assay, for pulmonary tuberculosis
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Authors : Adu-Gyamfi et al., International journal of infectious diseases
2020-08 - Effect of repetitive transcranial magnetic stimulation on the kynurenine pathway in stroke patients
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2019-08 - Traumatic injury leads to inflammation and altered tryptophan metabolism in the juvenile rabbit brain
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Authors : Zhang et al., Journal of Neurotrauma
2018-09 - Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice
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2018-07 - Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats
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Authors : Martin-Hernandez et al., Molecular Neurobiology
2018-05 - Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas: A Phase 2 Clinical Trial
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2018-01 - Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections
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Authors : Ziklo et al., Frontiers in cellular and infection microbiology
2018-01
