Kynurenine/Kynurenic Acid/Quinolinic Acid ELISA pack (3-KYNs ELISA pack)

Ref: ISE-220102R
Research ELISA kits (RUO)ELISAKynurenine pathwayTryptophan metabolism
DatasheetMSDS KynurenineProtocol KynurenineMSDS Kynurenic AcidProtocol Kynurenic AcidMSDS Quinolinic AcidProtocol Quinolinic Acid

The Kynurenine/Kynurenic Acid/Quinolinic acid ELISA pack enables quantitative measurements of tryptophan catabolism along the kynurenine pathway in large numbers of samples. Intended for research use only, the three kits included in the pack are ready to use. Highly sensitive, with a minimum sample volume of 25-50µL, they enable pre-clinical and clinical sample testings.

Sample type Plasma, Serum
Kit capacity 3 x 96 tests
Sensitivity LoD KYN: 47.5ng/ml

LoD KYNA: 0.53ng/ml

LoD QA: 6ng/ml

Range KYN: 100 – 10000ng/ml

KYNA: 1.40 – 74ng/ml
QA: 25 – 2000ng/ml

Reactivity Reacts with all species
References Individual kits cited in over 40 papers
Size

3 x 96 wells

1,300.00

76 in stock

Quantity
Total

1,300.00

Worldwide shipping

Select delivery location

Product overview

Product name Kynurenine/Kynurenic Acid/Quinolinic Acid ELISA pack
Description Three enzyme immunoassays (ELISA) allowing the quantitative determination of L-Kynurenine, Kynurenic acid and Quinolinic acid in serum samples. For research use only
Labels RUO
Format 3 x 96-well plate
Samples Serum
Minimum sample volume 20-50µL
Reactivity Reacts with all species
Standard range KYN: 100 – 10000ng/ml
KYNA: 1.40 – 74ng/mlQA: 200 – 2000µg/ml
Sensitivity

LoD KYN: 47.5ng/ml
LoD KYNA: 0.53ng/ml

LoD QA: 6ng/ml

Specificity No significant cross-reactivity was observed analogs for each kit. See product pages for L-Kynurenine ELISAKynurenic acid ELISA and Quinolinic acid ELISA
Storage Store at 2-8°C for to 6 months
Datasheets Instructions for use – KYN kitInstructions for use – KYNA kitInstructions for use – QA kit

Sample collection & storage Serum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands. Store samples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months)
Sample preparation KYN: Sample acylation (90 min)

KYNA: Sample derivatization (90 min)
QA: Sample acylation (120 min)

ELISA Antisera overnight incubation, revelation and read steps (1h)
Detailed protocol Instructions for use – KYN kitInstructions for use – KYNA kitInstructions for use – QA kit

Product citation

  • Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress
    Check article
    Authors : Letenneur et al., Nutrients
    2023-10
  • Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study
    Check the article
    Authors : Onning et al., Nutrients
    2023-08
  • Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
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    Authors : Dongen et al., bioRxiv
    2023-07
  • Advances in kynurenine analysis
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    Authors : Mrstna et al., Clinica Chimica Acta
    2023-07
  • Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions
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    Authors : Cremone et al., Biomedicines
    2023-04
  • Priming Mesenchymal Stem/Stromal Cells with a Combination of a Low Dose of IFN- and Bor_tezomib Results in Potent Suppression of Pathogenic Th17 Immunity Through the IDO1-AHR Axis
    Check the article
    Authors : Park et al., Stem Cells
    2022-10
  • IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma
    Check the article
    Authors : Struckmeier et al., Journal of Cancer Reasearch & Clinical Oncology
    2022-08
  • Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
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    Authors : Sugisawa et al., Cell reports
    2022-03
  • Alzheimer’s-like signaling in brains of COVID-19 patients
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    Authors : Reiken et al., Alzheimer's & Dementia
    2022-02
  • Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo
    Check the article
    Authors : Siska et al., eBioMedicine
    2021-12
  • Cancer-associated fibroblasts educate normal fibroblaststo facilitate cancer cell spreading and T-cell suppression
    Check the article
    Authors : Itoh et al., Molecular Oncology
    2021-11
  • Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma
    Check the article
    Authors : Pospíšková et al., Pteridines
    2021-11
  • Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway
    Check the article
    Authors : Kim et al., Oncoimmunology
    2021-11
  • Apathy is not associated with a panel of biomarkers in older adults with HIV disease
    Check the article
    Authors : Wood et al., Journal of psychosomatic research
    2021-11
  • Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives
    Check the article
    Authors : Sadok et al., Sensors
    2021-10
  • Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial
    Check the article
    Authors : Chaiyasut et al, Foods
    2021-07
  • STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer
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    Authors : Lee et al., Journal of Immunotherapy of Cancer
    2021-06
  • Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways
    Check the article
    Authors : MacDowell et al., Frontiers in Pharmacology
    2021-05
  • Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza
    Check the article
    Authors : Jung Cho et al., European Respiratory Journal
    2021-05
  • IDO1-mediated Trp-kynurenine-AhR signal activation induces stemness and tumor dormancy in oral squamous cell carcinomas
    Check the article
    Authors : Anzai et al., Oral Science International
    2021-04
  • Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
    Check the article
    Authors : Bekki et al., PloS one
    2020-10
  • Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans
    Check the article
    Authors : Baumgartner et al., Journal of internal medicine
    2020-08
  • Effect of repetitive transcranial magnetic stimulation on the kynurenine pathway in stroke patients
    Check the article
    Authors : Masachika et al., Clinical neuroscience
    2020-06
  • Evaluating the potential role of tryptophan in calf milk replacers to facilitate weaning
    Check the article
    Authors : Yeste et al., Journal of Dairy Science
    2020-05
  • IDO Targeting in Sarcoma: Biological and Clinical Implications
    Check the article
    Authors : Nafia et al., Frontiers in immunology
    2020-03
  • Selective Killing of Activated T Cells by 5- Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
    Check the article
    Authors : Darvekar et al., Cancers
    2020-02
  • A highly efficient modality to block the degradation of tryptophan for cancer immunotherapy: locked nucleic acid-modified antisense oligonucleotides to inhibit human indoleamine 2,3-dioxygenase 1/tryptophan 2,3-dioxygenase expression
    Check the article
    Authors : Klar et al., Cancer Immunol Immunother
    2020-01
  • Physical exercise prevents mice from L-Kynurenine-induced depression-like behavior
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    Authors : Su et al., Asian Journal of Psychatry
    2019-12
  • Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8 + T-Cell-Dependent Tumor Activity
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    Authors : Watanabe et al., Clinical Cancer Research
    2019-11
  • Lactobacillus maintains healthy gut mucosa by producing L-Ornithine
    Check the article
    Authors : Qi et al., Communications Biology
    2019-05
  • Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway
    Check the article
    Authors : Allison et al., American Journal of Psycology
    2019-01
  • Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice
    Check the article
    Authors : Walker et al., Molecular Psychiatry
    2018-07
  • Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats
    Check the article
    Authors : Martin-Hernandez et al., Molecular Neurobiology
    2018-05
  • Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas: A Phase 2 Clinical Trial
    Check the article
    Authors : Toulmonde et al., JAMA oncology
    2018-01
  • Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections
    Check the article
    Authors : Ziklo et al., Frontiers in cellular and infection microbiology
    2018-01
  • In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis
    Check the article
    Authors : Gautam et al., Proceedings of the National Academy of Sciences of the USA
    2018-01
  • The peroxyl radical-induced oxidation of Escherichia coli FtsZ and its single tryptophan mutant (Y222W) modifies specific side-chains, generates protein cross-links and affects biological function
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    Authors : Escobar-Alvarez et al., Free radical biology & medicine
    2017-07
  • Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway
    Check the article
    Authors : Lee et al., Proceedings of the Nation Academy of Sciences of the USA
    2017-07
  • Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
    Check the article
    Authors : Maliniemi et al., Oncoimmunology
    2017-02

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