Kynurenine/Kynurenic Acid/Quinolinic Acid ELISA pack (3-KYNs ELISA pack)

Ref: ISE-220102R
Kynurenine pathwayTryptophan metabolismResearch ELISA kits (RUO)ELISA
DatasheetMSDS KynurenineProtocol KynurenineMSDS Kynurenic AcidProtocol Kynurenic AcidMSDS Quinolinic AcidProtocol Quinolinic Acid

The Kynurenine/Kynurenic Acid/Quinolinic acid ELISA pack enables quantitative measurements of tryptophan catabolism along the kynurenine pathway in large numbers of samples. Intended for research use only, the three kits included in the pack are ready to use. Highly sensitive, with a minimum sample volume of 25-50µL, they enable pre-clinical and clinical sample testings.

Sample type Plasma, Serum
Kit capacity 3 x 96 tests
Sensitivity LoD KYN: 47.5ng/ml

LoD KYNA: 0.53ng/ml

LoD QA: 6ng/ml

Range KYN: 100 – 10000ng/ml

KYNA: 1.40 – 74ng/ml
QA: 25 – 2000ng/ml

Reactivity Reacts with all species
References Individual kits cited in over 40 papers

3 x 96 wells


75 in stock



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Product overview

Product name Kynurenine/Kynurenic Acid/Quinolinic Acid ELISA pack
Description Three enzyme immunoassays (ELISA) allowing the quantitative determination of L-Kynurenine, Kynurenic acid and Quinolinic acid in serum samples. For research use only
Labels RUO
Format 3 x 96-well plate
Samples Serum
Minimum sample volume 20-50µL
Reactivity Reacts with all species
Standard range KYN: 100 – 10000ng/ml
KYNA: 1.40 – 74ng/mlQA: 200 – 2000µg/ml

LoD KYN: 47.5ng/ml
LoD KYNA: 0.53ng/ml

LoD QA: 6ng/ml

Specificity No significant cross-reactivity was observed analogs for each kit. See product pages for L-Kynurenine ELISAKynurenic acid ELISA and Quinolinic acid ELISA
Storage Store at 2-8°C for to 6 months
Datasheets Instructions for use – KYN kitInstructions for use – KYNA kitInstructions for use – QA kit

Sample collection & storage Serum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands. Store samples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months)
Sample preparation KYN: Sample acylation (90 min)

KYNA: Sample derivatization (90 min)
QA: Sample acylation (120 min)

ELISA Antisera overnight incubation, revelation and read steps (1h)
Detailed protocol Instructions for use – KYN kitInstructions for use – KYNA kitInstructions for use – QA kit

Product citation

  • Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress
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    Authors : Letenneur et al., Nutrients
  • Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study
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    Authors : Onning et al., Nutrients
  • Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
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    Authors : Dongen et al., bioRxiv
  • Advances in kynurenine analysis
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    Authors : Mrstna et al., Clinica Chimica Acta
  • Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions
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    Authors : Cremone et al., Biomedicines
  • Priming Mesenchymal Stem/Stromal Cells with a Combination of a Low Dose of IFN- and Bor_tezomib Results in Potent Suppression of Pathogenic Th17 Immunity Through the IDO1-AHR Axis
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    Authors : Park et al., Stem Cells
  • IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma
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    Authors : Struckmeier et al., Journal of Cancer Reasearch & Clinical Oncology
  • Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
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    Authors : Sugisawa et al., Cell reports
  • Alzheimer’s-like signaling in brains of COVID-19 patients
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    Authors : Reiken et al., Alzheimer's & Dementia
  • Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo
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    Authors : Siska et al., eBioMedicine
  • Cancer-associated fibroblasts educate normal fibroblaststo facilitate cancer cell spreading and T-cell suppression
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    Authors : Itoh et al., Molecular Oncology
  • Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma
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    Authors : Pospíšková et al., Pteridines
  • Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway
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    Authors : Kim et al., Oncoimmunology
  • Apathy is not associated with a panel of biomarkers in older adults with HIV disease
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    Authors : Wood et al., Journal of psychosomatic research
  • Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives
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    Authors : Sadok et al., Sensors
  • Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial
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    Authors : Chaiyasut et al, Foods
  • STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer
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    Authors : Lee et al., Journal of Immunotherapy of Cancer
  • Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways
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    Authors : MacDowell et al., Frontiers in Pharmacology
  • Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza
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    Authors : Jung Cho et al., European Respiratory Journal
  • IDO1-mediated Trp-kynurenine-AhR signal activation induces stemness and tumor dormancy in oral squamous cell carcinomas
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    Authors : Anzai et al., Oral Science International
  • Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
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    Authors : Bekki et al., PloS one
  • Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans
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    Authors : Baumgartner et al., Journal of internal medicine
  • Effect of repetitive transcranial magnetic stimulation on the kynurenine pathway in stroke patients
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    Authors : Masachika et al., Clinical neuroscience
  • Evaluating the potential role of tryptophan in calf milk replacers to facilitate weaning
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    Authors : Yeste et al., Journal of Dairy Science
  • IDO Targeting in Sarcoma: Biological and Clinical Implications
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    Authors : Nafia et al., Frontiers in immunology
  • Selective Killing of Activated T Cells by 5- Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
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    Authors : Darvekar et al., Cancers
  • A highly efficient modality to block the degradation of tryptophan for cancer immunotherapy: locked nucleic acid-modified antisense oligonucleotides to inhibit human indoleamine 2,3-dioxygenase 1/tryptophan 2,3-dioxygenase expression
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    Authors : Klar et al., Cancer Immunol Immunother
  • Physical exercise prevents mice from L-Kynurenine-induced depression-like behavior
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    Authors : Su et al., Asian Journal of Psychatry
  • Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8 + T-Cell-Dependent Tumor Activity
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    Authors : Watanabe et al., Clinical Cancer Research
  • Lactobacillus maintains healthy gut mucosa by producing L-Ornithine
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    Authors : Qi et al., Communications Biology
  • Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway
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    Authors : Allison et al., American Journal of Psycology
  • Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice
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    Authors : Walker et al., Molecular Psychiatry
  • Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats
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    Authors : Martin-Hernandez et al., Molecular Neurobiology
  • Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas: A Phase 2 Clinical Trial
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    Authors : Toulmonde et al., JAMA oncology
  • Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections
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    Authors : Ziklo et al., Frontiers in cellular and infection microbiology
  • In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis
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    Authors : Gautam et al., Proceedings of the National Academy of Sciences of the USA
  • The peroxyl radical-induced oxidation of Escherichia coli FtsZ and its single tryptophan mutant (Y222W) modifies specific side-chains, generates protein cross-links and affects biological function
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    Authors : Escobar-Alvarez et al., Free radical biology & medicine
  • Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway
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    Authors : Lee et al., Proceedings of the Nation Academy of Sciences of the USA
  • Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
    Check the article
    Authors : Maliniemi et al., Oncoimmunology

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