Quinolinic acid Antibody – Mouse Monoclonal

Ref: IS002
Kynurenine pathwayTryptophan metabolismToxinsMonoclonal AntibodiesICCIFIHC
DatasheetMSDS

This mouse monoclonal antibody to Quinolinic acid was validated for IF & IHC in human brain tissues. It was recently used in 3 papers to evidence the role of Quinolinic acid in atherogenesis & glioblastoma.

ClonalityMonoclonal antibody (clone 4E11-G3)
HostMouse
Valided applicationsIHC / IF
ReactivityReacts with all species
ReferencesNot yet cited to our knowledge
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Format50µL
ReferencesCited in 3 papers
Size

50µl

440.00

90 in stock

Quantity
Total

440.00

Worldwide shipping

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Product overview

Product nameQuinolinic acid antibody
SynonymsPyridine-2,3-dicarboxylic acid antibody

2,3-pyridinedicarboxylic acid antibody

3,4-Pyridinedicarboxylic acid antibody

Pyridine-3,4-dicarboxylic acid antibody

ImmunogenConjugated quinolinic acid
IsotypeIgG1 k chain
Cloneclone 4E11-G3
SpecificityWhen tested in competitive ELISA, the anti-Quinolinic acid antibody did not show any significant cross reactivity with Picolinic and Quinaldic acid conjugates
Lot number140201
Expiration date2025-02-01

Storage

FormLiquid
PurityPurified IgG
Concentration0,5mg/ml
Storage
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles
Material safety datasheetDownload MSDS

Immunohistochemistry (IHC)Dilute at 1:100-1:1000. Perform heat antigen retrieval (pH=9) before initiating IHC staining protocol on paraffin-embedded and frozen sections
Immunofluorescence (IF)Dilute at 1:50-1:500 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate fluorescent dyes conjugated secondary antibody
CommentsOptimal working dilutions must be determined by the end-user
RestrictionsFor research use only

Product citation

  • Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
    Check the article
    Authors : Dongen et al., bioRxiv
    2023-07
  • Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis
    Check the article
    Authors : Kesarwani et al., Nature Communications
    2023-03
  • Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
    Check the article
    Authors : Sugisawa et al., Cell reports
    2022-03

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